Clinical Effects and Economic Impact of Dutasteride and Finasteride Therapy in Italian Men with Lower Urinary Tract Symptoms

December 2013 in “ Archivio italiano di urologia, andrologia ”

Luca Cindolo, Francesco Berardinelli, Caterina Fanizza, Marilena Romero, Luisella Pirozzi, Fabiola Raffaella Tamburro, Fabrizio Pellegrini, Fabio Neri, Andrea Pitrelli, Luigi Schips

dutasteride finasteride benign prostatic hyperplasia BPH lower urinary tract symptoms LUTS prostate cancer pharmacoeconomic analysis Avodart Propecia

TLDR Dutasteride reduces hospitalization and prostate cancer risk compared to finasteride, potentially offsetting its higher cost.

This study from 9 years ago compared the clinical effects and economic impact of dutasteride and finasteride therapy in Italian men with lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). The study found that dutasteride was associated with a reduced likelihood of hospitalization for BPH-related surgery and newly detected prostate cancer compared to finasteride. The pharmacoeconomic analysis also suggested that the higher price of dutasteride may be offset by decreased medical resource consumption, resulting in a net budget impact in favor of dutasteride. However, the study was limited by its retrospective, non-randomized nature and the lack of information about symptomatic burden of the disease, urodynamic parameters, baseline PSA values, number and kind of core biopsies, and Gleason score. Further clinical trials are warranted to confirm these results and evaluate the long-term effectiveness of these drugs.

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Research cited in this study

2 / 2 results

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

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6 / 1000+ results

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 1 year ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community Why does finasteride stop working?

in Finasteride/Dutasteride 26 upvotes 2 months ago

Finasteride may seem less effective over time due to increased DHT sensitivity or aging, but it still suppresses DHT. Switching to dutasteride offers stronger DHT suppression but may increase estrogen levels.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Wtf have we been doing for the last 30 years

in Treatment 526 upvotes 4 days ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 3 months ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 4 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

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research Combined Treatment of Benign Prostatic Syndrome with Tamsulosin and Finasteride: Literature Review and Prescription Data

1 citations, May 2017 in “Urologe A”

Using tamsulosin and finasteride together for benign prostatic syndrome has increased and shows improvement in symptoms, but more reliable comparisons are needed.