15 citations
,
March 2015 in “Experimental Dermatology” Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
10 citations
,
March 2008 in “Journal of Zoo and Wildlife Medicine” This case study describes successful treatment of a siamang's persistent Microsporum canis infection using a sustained-release clotrimazole varnish, leading to lesion resolution after two years of clinical signs.
August 2022 in “Scholars academic journal of pharmacy” This study involved formulating an invasome gel loaded with clotrimazole for treating fungal infections and assessed its various properties like spreadability and in vitro drug diffusion.
January 2026 in “Physical Education Health and Social Sciences” This study found that integrating Lactobacillus-rich probiotic nutrition and fractional CO₂ laser therapy with clotrimazole in mucoadhesive hydrogels significantly improved clinical and structural outcomes for women with recurrent vulvovaginal candidiasis, suggesting a promising advanced therapy, though further validation in larger trials is needed.
109 citations
,
March 2011 in “Journal of controlled release” This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.
75 citations
,
January 1997 in “Journal of ethnopharmacology” This study found that Santolina oil was effective in controlling experimental candidiasis in both in vitro and in vivo settings and enhanced the effectiveness of clotrimazole against Candida albicans in vitro.
66 citations
,
January 1987 in “Journal of Investigative Dermatology” This study found that enzyme activity critical to cancer induction by polycyclic aromatic hydrocarbons in human hair follicles increased after using a crude coal tar-containing shampoo for four days and was substantially inhibited by imidazole compounds.
65 citations
,
April 2000 in “The Laryngoscope” This study concluded that clotrimazole, miconazole, and tolnaftate appeared safe in guinea pigs, whereas gentian violet showed potential for severe ototoxicity, and nystatin left a concerning residue.
42 citations
,
January 2002 in “Skin Pharmacology and Physiology” This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.
24 citations
,
November 2018 in “International Journal of Molecular Sciences” This review discusses ethosomes as lipid carriers that enhance drug penetration into deep skin layers and underscores the need for advanced research on their pharmaceutical applications, but it reports no clinical outcomes.
22 citations
,
June 1991 in “Clinical Therapeutics” This study found that once-daily oxiconazole cream effectively treats tinea infections, achieving at least 80% cure rates, and shows comparable efficacy to other antifungal creams with similar tolerability.
14 citations
,
January 1991 in “PubMed” This study reports that once-daily oxiconazole cream effectively achieves mycologic and clinical cures for various fungal infections, with success rates of at least 80% in patients.
12 citations
,
June 2011 in “Journal of Dermatological Case Reports” This case report describes successful treatment of trichomycosis axillaris, a bacterial infection of hair shafts, using shaving and topical antibiotics, resulting in complete odor elimination within weeks.
9 citations
,
January 1983 in “Journal of Chromatography B Biomedical Sciences and Applications” This study found that enzyme activity related to cancer induction by polycyclic aromatic hydrocarbons can be increased by using a shampoo containing crude coal tar and significantly inhibited by imidazole compounds in human hair follicles.
7 citations
,
September 2021 in “Antimicrobial Agents and Chemotherapy” This study found that olorofim demonstrated potent in vitro and in vivo antifungal activity against dermatophytes, resolving skin lesions in a guinea pig model similar to clotrimazole, suggesting it may be a promising treatment for dermatophytosis.
7 citations
,
September 2013 in “Current Dermatology Reports” This review summarizes existing literature on the safety of commonly used dermatologic medications during pregnancy but does not present new clinical findings, aiming to assist physicians with prescribing decisions.
5 citations
,
January 2020 in “Veterinary Dermatology” In this study, researchers evaluated the antifungal effectiveness of topical products on infected kitten hair, finding most were effective after one application, with enilconazole and lime sulfur showing residual activity; however, 0.15% ketoconazole with chlorhexidine had no such lasting effect.
4 citations
,
December 2022 in “Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences” This study conducted in Egypt evaluated antifungal treatments for sheep with dermatophytosis, finding that tioconazole cream, clotrimazole spray, and fluconazole capsules were effective, with tioconazole cream providing an easily applicable and highly effective topical option, achieving a 100% cure rate in the short term.
4 citations
,
April 1986 in “Cancer Letters” This study found no significant difference in glutathione-S-epoxide transferase activity in hair follicles between smokers and non-smokers, suggesting this enzyme's levels may not indicate polycyclic aromatic hydrocarbon-related cancer risk.
1 citations
,
June 2011 in “Journal of Dermatological Case Reports” This case report describes a 38-year-old patient with trichomycosis axillaris, successfully treated with shaving, 3% erythromycin cream, and clotrimazole powder.
July 2026 in “Current Trends in Biotechnology and Pharmacy” In this study, a new herbal hair oil formulation, consisting of plant-derived antifungal agents and natural stabilizers, was developed and demonstrated strong antifungal activity, skin compatibility, and additional hair health benefits in preclinical evaluations, offering a potential alternative for managing fungal scalp infections.
April 2026 in “Ankara Üniversitesi Veteriner Fakültesi Dergisi” This study found that Mueller-Hinton Agar performed better than Dermasel Agar for antifungal susceptibility testing of feline dermatophytes, providing reliable susceptibility data for effective antifungal therapy.
September 2025 in “Animals” In this study, dermatophytosis was prevalent among 52% of dogs and 70% of cats with skin lesions, with younger animals facing higher infection risks; combined itraconazole, clotrimazole, supportive care, and vaccination led to the fastest recovery.
This report describes a case where a patient's rash initially treated as atopic dermatitis with topical steroids was later diagnosed as tinea incognito, an atypical dermatophyte infection that worsened due to steroid use, but was effectively treated with oral and topical antifungals.
September 2024 in “The Indian Veterinary Journal” This case report describes a three-month-old male Labrador pup with dermatophytosis, diagnosed through clinical signs and a Woods lamp test, which successfully recovered from the infection with a four-week treatment regimen involving topical and oral therapies.
August 2019 in “International journal of current microbiology and applied sciences” This study found that among 86 skin scrapings from various dog breeds with ringworm lesions, Microsporum species were the predominant fungal infection, with Labradors showing the highest infection rate. Miconazole was most effective in antifungal susceptibility tests.
January 2016 in “Elsevier eBooks” This article discusses dermatophycosis, a fungal infection affecting various animals, and outlines its transmission, diagnosis, treatment, and prevention methods, but reports no new research findings.
July 2000 in “The Pediatric Infectious Disease Journal” This case report highlights tinea faciei as a potential diagnosis for vesicular lesions in neonates, suggesting its consideration over more invasive diagnostics for similar presentations.
January 2023 in “Indian Dermatology Online Journal” This case report describes two instances of superficial dermatophytosis in neonates, highlighting the unusual occurrence and successful resolution with topical antifungal treatment.
October 2023 in “Journal of the American Academy of Dermatology” This source reports that clascoterone cream has been approved in the U.S. for treating acne vulgaris in patients aged 12 and older, suggesting it works by competing with dihydrotestosterone at androgen receptors to mitigate acne's effects.