Immediate and Residual Antifungal Activity of Compounds Used for Whole Body and Adjuvant Topical Therapy Against Microsporum Canis: An In Vitro Study
January 2020
in “
Veterinary Dermatology
”
Studysummary In this study, researchers evaluated the antifungal effectiveness of topical products on infected kitten hair, finding most were effective after one application, with enilconazole and lime sulfur showing residual activity; however, 0.15% ketoconazole with chlorhexidine had no such lasting effect. Our plain-language summary of this paper — not a Tressless recommendation.
This study assessed the antifungal efficacy of 14 topical products against Microsporum canis using hair samples from infected kittens. All products were effective against spores, but miconazole 0.2% and ketoconazole 0.15% needed three treatments for complete disinfection, while others required only one. Residual activity was consistent up to 72 hours post-treatment. Lime sulfur and enilconazole were effective for whole body applications, and clotrimazole 1% and terbinafine 1% showed residual activity for focal therapy. The study recommended enilconazole and lime sulfur twice weekly, and daily or alternate-day adjuvant focal therapy for optimal antifungal activity.
