Olorofim Effectively Eradicates Dermatophytes In Vitro and In Vivo

Olorofim, a novel antifungal targeting pyrimidine biosynthesis, showed high efficacy against dermatophytes in vitro with MIC values of 0.015 to 0.06 mg/liter and in vivo using a guinea pig model infected with Microsporum gypseum. Daily topical application of olorofim for 1 week resolved skin lesions and restored normal hair growth, comparable to clotrimazole. The study, involving nine guinea pigs, suggests olorofim as a promising treatment for dermatophytosis, though further research is needed to evaluate its efficacy against other dermatophytes and its pharmacokinetics.