Ototoxicity of Common Topical Antimycotic Preparations

    April 2000 in “ The Laryngoscope ”
    Lawrence W.C. Tom
    TLDR Clotrimazole, miconazole, and tolnaftate are likely safe, but gentian violet is risky.
    The study investigated the ototoxic effects of five topical antimycotic agents—clotrimazole, miconazole, nystatin, tolnaftate, and gentian violet—on guinea pigs by measuring hair cell loss. Results showed that clotrimazole, miconazole, and tolnaftate did not cause hair cell loss in the first two cochlear turns, and nystatin showed no evidence of ototoxicity, although it left a persistent residue. Gentian violet, however, caused significant vestibular damage and middle ear inflammation, preventing accurate hair cell counts. The study concluded that while extrapolating to humans requires caution, clotrimazole, miconazole, and tolnaftate appear safe, whereas gentian violet poses a risk of severe damage. The residue from nystatin highlights the importance of considering both active ingredients and vehicles in safety evaluations.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 8 results

      community Can valisone solution cause hairloss?

      in Question  1 upvotes 6 years ago
      A user is concerned that prolonged use of valisone (betamethasone) and clotrimazole solution for scalp dermatitis may be causing hair thinning and loss. They noticed thinning in the area where the solution was applied.

      community Will stopping ketoconazole make a difference?

      in Ketoconazole  11 upvotes 8 months ago
      The user has been using finasteride and ketoconazole for hair loss and is considering changing shampoos due to dryness caused by ketoconazole. Responses suggest that stopping ketoconazole won't affect hair loss unless the user has seborrheic dermatitis, and recommend using conditioner or using ketoconazole shampoo less frequently.

      community Yeah, it’s working 👍🏻 Nov 2023 to March 2024

      in Progress Pictures  63 upvotes 9 months ago
      Animajax, who started off completely bald, has seen hair regrowth using finasteride 1.25mg, oral minoxidil 2.5mg, occasional topical minoxidil, dermastamping, benzoyl peroxide, and tretinoin. They recently added nizoral and plan to switch to a topical solution combining minoxidil and dutasteride.

      community The ultimate Regimen for density and thick ess

      in Treatment  10 upvotes 2 months ago
      The regimen for hair loss includes topical finasteride, clascoterone, tretinoin, minoxidil, oral saw palmetto, beta-sitosterol, vitamin D, microneedling, and anti-fungal shampoo. Expected benefits are increased hair growth and density, with considerations for potential skin irritation and interactions between treatments.

      community Should I start minoxidil before finasteride?

      in Treatment  3 upvotes 1 year ago
      A 21-year-old male from Bangladesh is experiencing hair loss and was advised by a dermatologist to use ketoconazole shampoo, anti-fungal treatments, biotin, and 5% minoxidil, with finasteride to be considered after six months. The user is unsure whether to follow this advice or start finasteride immediately alongside minoxidil.

    Similar Research

    5 / 169 results