Oxiconazole Nitrate: Pharmacology, Efficacy, And Safety Of A New Imidazole Antifungal Agent
January 1991
in “
PubMed
”
New to Clotrimazole? There is a guide in the encyclopedia. Read the guide → Studysummary This study reports that once-daily oxiconazole cream effectively achieves mycologic and clinical cures for various fungal infections, with success rates of at least 80% in patients. Our plain-language summary of this paper — not a Tressless recommendation.
Oxiconazole nitrate (1%) cream was introduced in the U.S. in 1989 for treating fungal infections like tinea pedis, tinea cruris, and tinea corporis with once-daily application. It was effective against various dermatophytes and maintained fungicidal concentrations in the skin for over 16 hours. Clinical trials showed that a 4-week treatment for tinea pedis and a 2-week treatment for other infections resulted in at least 80% cure rates. Oxiconazole was as effective as or more effective than other antifungal creams like miconazole and clotrimazole, with similar tolerability and better irritation profile compared to econazole. It had negligible systemic absorption, making it suitable for patients with compliance issues.
