October 2023 in “Biomimetics” This study developed a biocompatible hair-dyeing technology using a dark polyphenol complex, which demonstrated effective hair coating, improved mechanical strength, and strong antioxidant properties while maintaining high cell viability.
June 2025 in “Frontiers in Bioengineering and Biotechnology” In this study, the researchers observed that a recombinant human collagen complex with nicotinamide promoted hair growth in rat models, increased hair follicle stem cell survival, and enhanced key protein expression, suggesting potential benefits for hair health and loss prevention.
September 2024 in “Journal of the American Academy of Dermatology” This study found that a new compounded topical solution for alopecia was clinically tolerable and did not cause irritation, while also showing potential to enhance hair growth through fibroblast proliferation and gene expression.
September 2016 in “Journal of Dermatological Science” This study found that P. cornucopiae extract showed antioxidant and protective effects on human skin fibroblasts, suggesting its potential as an antiaging agent by preventing oxidative stress-induced collagen breakdown.
June 2022 in “Research journal of topical and cosmetic sciences” This study found that taking 500mg of Trichovitals® daily for 12 weeks was linked to significant improvements in hair thickness, reduced hair loss, and enhanced hair growth in young adults.
3 citations
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January 2017 in “Journal of cosmetology & trichology” This study reports that a nutritional complex may improve hair density and quality, with in vitro findings demonstrating inhibition of 5α-reductase, and participants noting reduced hair loss and greasiness.
January 2013 in “Российский журнал кожных и венерических болезней” This study found that intradermal injections of group B vitamins and cystin B6 complex improved scalp circulation, supported hair growth, and reduced hair loss in patients with diffuse alopecia.
2 citations
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May 2025 in “PLoS ONE” This study found that a 4:1 combination of Rhynchosia nulubilis and Polygonum multiflorum extracts significantly promoted the proliferation of human dermal papilla cells and alleviated testosterone-induced cytotoxicity, suggesting potential for treating hair loss and related disorders through a synergistic approach.
May 2026 in “Journal of Cosmetic Dermatology” This study found that a nutritional supplement containing millet extract, pantothenic acid, L-cystine, and biotin significantly increased hair density, improved hair growth and appearance, and reduced hair loss by 59% in 112 healthy subjects with light diffuse hair loss over 12 weeks.
August 2026 in “Frontiers in Nutrition” This study reports that combining ergothioneine, collagen peptides, and sodium hyaluronate improved skin parameters like hydration, elasticity, and wrinkle reduction in Chinese women, while ex vivo data indicated enhanced antioxidant action and structural support, suggesting potential for anti-aging nutricosmetics.
1 citations
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September 2022 in “KnE medicine” This study demonstrated that a nanoemulsion hair tonic containing 7% candlenut oil accelerated hair growth more effectively in Mus musculus than both lower concentrations and a commercial ginseng tonic.
18 citations
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October 2018 in “Nutrients” This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.
1 citations
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July 2022 in “Bandung Conference Series. Pharmacy” This study found that a hair tonic formulation using candlenut oil as an active ingredient could significantly promote hair growth in rabbits, achieving 29.77 mm in 22 days.
February 2023 in “Aesthetic Cosmetology and Medicine” This review examines the health-promoting effects of medicinal plants used in nutricosmetics, highlighting their beneficial impact on skin physiology, but offers no new clinical results.
May 2026 in “International Journal of Cosmetic Science” In this study, researchers observed that using an Avena strigosa seed extract on chemically damaged hair significantly improved hair properties, including strength, gloss, and surface quality, by reinforcing keratin bonding and sealing cuticle damage.
This chapter reviews plant extract-based cosmeceuticals for hair care and hair loss but presents no new clinical findings, instead discussing active ingredients with supportive scientific data.
January 2023 in “Health science reports” In this study, oral Pycnogenol® intake was reported to significantly increase hair density and improve scalp microcirculation in Han Chinese menopausal women over six months.
1 citations
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May 2017 in “Journal of The American Academy of Dermatology” The moisturizer with phytol improved skin texture and reduced fine wrinkles better than the moisturizer without it.
December 2025 in “Cosmetics” In a laboratory study, researchers found that a novel Bioactive Crosslink Repair Complex improved both the protection and repair of chemically damaged hair, enhancing tensile strength, shine, and cuticle alignment when added to bleaching mixtures and leave-in conditioners.
January 2023 in “Applied sciences” This study suggests that Equisetum debile extracts, particularly the ethyl acetate fraction, may offer natural cosmeceutical benefits for treating hyperpigmentation, delaying skin aging, and remediating hair loss due to androgenic alopecia.
June 2026 in “Journal of Cosmetic Dermatology” This study reports that a novel multi-compound Blend, tested on ex vivo human hair follicles, promotes hair growth by enhancing elastin deposition and dermal papilla inductivity more effectively than isopropyl cloprostenate, suggesting benefits through elastogenesis and modulation of Wnt signaling.
September 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study introduces the MHS Hair Restoration Protocol, a systems-biology model targeting hair follicle health through the gut-microbiome-endocannabinoidome axis and innovative topical treatments, emphasizing a holistic approach to pattern hair loss.
This abstract introduces TrichoFoam™, a new foaming vehicle for compounding pharmacies, designed to be a gentle, non-irritating option for alopecia treatment, acknowledging that current topical treatments are limited and oral products may cause adverse effects.
16 citations
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November 2011 in “PubMed” This study found that a single intradermal injection of Hair Stimulating Complex significantly improved hair growth in men with androgenetic alopecia compared to placebo.
3 citations
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November 2018 in “Journal of cellular physiology” In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.
9 citations
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January 2006 in “Cutaneous and ocular toxicology” This study found that L-cystine, D-pantothenat, and miliacin can enhance the metabolic capacity and proliferation of human keratinocytes, with a combination of these additives potentially providing synergistic benefits in growth media.
1 citations
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August 2017 in “Journal of food and nutrition research” This study found that the black bean-licorice-biotae folium extract may improve hair diameter, scalp moisture, and sebum secretion, although its effect on hair density was not significant.
December 2025 in “Advanced Healthcare Materials” In this study, a new topical formulation containing amine-activated carboxymethyl chitosan and hydrolyzed extracellular matrix showed promising results in a mouse model by reducing oxidative stress, inflammation, and promoting hair regeneration, potentially offering an alternative treatment for inflammatory hair loss.
May 2026 in “Preprints.org” This study found that a supplement containing cystine, B vitamins, and minerals improved hair condition in 34 women with diffuse hair loss over six months, as evidenced by an increased anagen/telogen hair ratio, positive participant feedback, and no serious side effects.
July 2024 in “Skin Appendage Disorders” This study found that after 6 months of taking an oral supplement, patients with chronic telogen effluvium or androgenetic alopecia experienced a statistically significant increase in hair density and overall improved hair appearance compared to those taking a placebo, with the supplement being well tolerated.