Compounded Solution to Personalize Alopecia Management

September 2024 in “ Journal of the American Academy of Dermatology ”

Carolina C. V. Silva, Hudson Polonini

compounded topical solution alopecia minoxidil dutasteride finasteride fibroblast proliferation FGF-7 FGF-10 High-Performance Liquid Chromatography CTS hair loss Rogaine Propecia

TLDR The compounded topical solution is safe, stable, and effective for personalized alopecia treatment.

The study introduces a compounded topical solution (CTS) for personalized alopecia treatment, addressing the limitations of standard treatments. Involving 52 healthy volunteers, the study found no adverse reactions after 6 weeks, indicating good clinical tolerability. The solution's stability was confirmed using High-Performance Liquid Chromatography, showing compatibility with minoxidil and dutasteride or finasteride over extended periods. Additionally, CTS was shown to enhance fibroblast proliferation and increase FGF-7 and FGF-10 mRNA levels, suggesting a mechanism for promoting hair growth. These findings suggest CTS as a promising alternative or complementary treatment for alopecia.

View this study on jaad.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

Biomolecules of Fermented Tropical Fruits and Fermenting Microbes as Regulators of Human Hair Loss, Hair Quality, and Scalp Microbiota

research Biomolecules of Fermented Tropical Fruits and Fermenting Microbes as Regulators of Human Hair Loss, Hair Quality, and Scalp Microbiota

1 citations, April 2023 in “Biomolecules”

Fermented papaya and mangosteen in hair care products helped prevent hair loss and improve hair thickness.

research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

November 2020 in “Elsevier eBooks”

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

research Interventions for Female Pattern Hair Loss

21 citations, May 2016 in “The Cochrane library”

Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.

research Hair: What Is New in Diagnosis and Management?

46 citations, October 2012 in “Dermatologic Clinics”

Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.

research Medical Therapy for Frontal Fibrosing Alopecia: A Review and Clinical Approach

37 citations, April 2019 in “Journal of The American Academy of Dermatology”

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

Compounded Solution to Personalize Alopecia Management

Related Community Posts Join

community So what’s really the deal with dutasteride hairline ruining claims?

community Well here I am 3-4 years later.

community I bought a microscope, how does my scalp/hairs look? I've been suffering diffuse thinning and hair loss after covid and never recovered (2 yrs ago) I eat healthy, in shape and workout.

community Before and After, 5 years apart. Topical minoxidil once daily and dutasteride 0,5 mg per day

community Finasteride/dut. causes NAFLD,IR,diabetes,kidney dysfunction is it correct.