Compounded Solution to Personalize Alopecia Management

September 2024 in “ Journal of the American Academy of Dermatology ”

Carolina C. V. Silva, Hudson Polonini

compounded topical solution alopecia minoxidil dutasteride finasteride fibroblast proliferation FGF-7 FGF-10 High-Performance Liquid Chromatography CTS hair loss Rogaine Propecia

TLDR The compounded topical solution is safe, stable, and effective for personalized alopecia treatment.

The study introduces a compounded topical solution (CTS) for personalized alopecia treatment, addressing the limitations of standard treatments. Involving 52 healthy volunteers, the study found no adverse reactions after 6 weeks, indicating good clinical tolerability. The solution's stability was confirmed using High-Performance Liquid Chromatography, showing compatibility with minoxidil and dutasteride or finasteride over extended periods. Additionally, CTS was shown to enhance fibroblast proliferation and increase FGF-7 and FGF-10 mRNA levels, suggesting a mechanism for promoting hair growth. These findings suggest CTS as a promising alternative or complementary treatment for alopecia.

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