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This review discusses the potential benefits of a nutraceutical with biooptimized botanical extracts for treating hair loss and reports no new clinical results; ongoing studies aim to validate its efficacy.

This study concluded that a combination of millet seed extract, L-cystine, and calcium pantothenate may improve anagen hair rate in women with androgenetic alopecia over six months.

This study found that the 100% herbal complex extract, including Houttuynia cordata, significantly stimulated hair growth and increased hair density and weight in C57BL/6 mice, comparable to minoxidil treatment.

In this study, the herbal complex of Houttuynia cordata, Perilla frutescens var. acuta, and green tea promoted hair growth in C57BL/6 mice, enhancing regrowth and follicle development compared to controls.

In this study, testing Annurca apple extract on human follicle dermal papilla cells indicated its potential to prevent patterned hair loss by reducing oxidative stress and increasing factors involved in hair growth.

This study observed that taking 500mg/day of Microcore’s Muttaijow ComplexTM for 12 weeks significantly improved the appearance of skin, hair, and nails in healthy middle-aged adults.

In this in-vitro study on human hair follicle cultures, researchers reported that the HAIR & SCALP COMPLEX significantly enhanced hair bulb growth and dermal papilla regeneration compared to other treatments, suggesting a potential new approach for managing hair loss and promoting growth.

This study found that applying a red clover-chamomile complex extract ampoule for 4 weeks significantly improved hair density and shaft thickness at the hairline in participants with self-perceived decreased density.

In this study, a 12-week treatment with Angelicae Gigantis Radix and Glycyrrhizae Radix complex was well tolerated and showed therapeutic effects on moderate lower urinary tract symptoms in men.

This study found that a combination of oral compounds improved metabolic activity, cell viability, and proliferation in hair follicular keratinocytes, with L-cystine playing a key role in protection against oxidative stress.

This study reported that Cacumen Platycladi extract significantly reduced hair loss and increased hair density in a 12-week clinical trial, suggesting it may be a safe and effective natural treatment.

In this study, TrichotechTM, a phytocomplex derived from essential oils, enhanced fibroblast proliferation, increased FGF-7 and FGF-10 gene expression, and boosted collagen content in cultured human fibroblasts.

This study found that a phytosomal delivery system improved the bioavailability of Cuscuta reflexa extract compared to the plain extract, suggesting enhanced potential for this formulation.

This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.

This study found that a nutraceutical containing vitamins and trace elements was effective in reducing telogen strands and improving hair and nail conditions in individuals with telogen effluvium and brittle nails syndrome.

This study found that a novel Mito-Activator Complex, containing nicotinamide and epigallocatechin gallate, significantly increased hair density and growth in a 6-month human trial, with no adverse effects reported, potentially offering a new approach to hair loss treatment through mitochondrial activation.

This study found that Cornu cervi pantotrichum pharmacopuncture solution significantly promoted hair growth in mice by enhancing hair follicular cell proliferation and up-regulating FGF-7 expression.

This review discusses the bioactive compounds and biological activities of Polygonum multiflorum Thunb. and highlights concerns about its hepatotoxicity, but reports no new clinical results.

This report details the development of a PSR™ Terminalia extract with antioxidant and anti-aging potential, highlighting its rich composition in phenolic acids, polysaccharides, and organic acids, without new clinical results.

This study demonstrated that combining l-cystine and thiamin in a formulation may protect against UV-induced damage in growth-limited human epidermal keratinocytes in vitro.

In this study, researchers assessed the stability of various formulations in the TrichoConcept™ line for customized alopecia treatment. They found that the combinations remained stable from 14 to 180 days, supporting the use of these vehicles for enhancing therapeutic outcomes in hair loss treatments.

This study identified 43 compounds in Platycladi Cacumen, including flavonoids, and found significant chemical variation in flavonoid content across different regions and processed products.

This study found that forming inclusion complexes of DPCP with HPβCD using the 3D ground mixture method enhances its anti-inflammatory activity at lower doses compared to complexes with β-CD.

This trial found that intradermal injections of the Hair Stimulating Complex were well-tolerated and effectively stimulated hair growth and prevented hair loss in male pattern baldness participants over 18 weeks.

This study suggests that a complex of millet and wheat extract may enhance hair health by reducing oxidative stress and inflammation and potentially prolonging the anagen phase of hair growth in models.

In this study, the multifunctional Hair BB Cream containing botanical extracts and other ingredients improved hair combability, increased shine and strength, and provided UV protection, highlighting its potential as an effective hair care product.

In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.

In this quasi-experimental study, researchers explored the optimal formulation of a nanoemulsion containing candlenut ethanol extract, finding that specific combinations of tween 80, span 80, and sonication time affected its physical properties and stability, although further activity testing is needed.