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    Glossary CD8

    protein on cytotoxic T cells that kills infected cells

    CD8 is a protein found on the surface of certain immune cells, specifically a subset of T cells known as cytotoxic T cells or CD8+ T cells. These cells play a crucial role in the immune system by directly killing infected or cancerous cells.

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    1. High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata JCI insight · 2018 · 46 citations
    2. CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment Immunity · 2024 · 28 citations
    3. Changes in distribution pattern of CD8 lymphocytes in the scalp in alopecia areata during treatment with diphencyprone Archives of dermatological research · 2007 · 27 citations
    4. A mouse model of vitiligo based on endogenous auto-reactive CD8 + T cell targeting skin melanocyte Cell Regeneration · 2022 · 24 citations
    5. Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level Indian Journal of Dermatology, Venereology and Leprology · 2012 · 24 citations
    6. SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction Oncotarget · 2017 · 16 citations
    7. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients 2018 · 15 citations
    8. Diphencyprone and topical tacrolimus as two topical immunotherapeutic modalities. Are they effective in the treatment of alopecia areata among Egyptian patients? A study using CD4, CD8 and MHC II as markers Journal of dermatological treatment · 2010 · 13 citations
    9. Antroquinonol Exerts Immunosuppressive Effect on CD8<sup>+</sup> T Cell Proliferation and Activation to Resist Depigmentation Induced by H<sub>2</sub>O<sub>2</sub> Oxidative medicine and cellular longevity · 2017 · 11 citations
    10. CD8+ mycosis fungoides clinically masquerading as alopecia areata Journal of Cutaneous Pathology · 2016 · 8 citations
    11. CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice Journal of comparative pathology · 2015 · 7 citations
    12. Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases International journal of molecular sciences · 2023 · 6 citations
    13. CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia Experimental dermatology · 2017 · 6 citations
    14. Human T‐lymphotropic virus 1 (HTLV‐1)‐associated lichenoid dermatitis induced by CD8<sup>+</sup> T cells in HTLV‐1 carrier, HTLV‐1‐associated myelopathy/tropical spastic paraparesis and adult T‐cell leukemia/lymphoma The Journal of Dermatology · 2015 · 5 citations
    15. Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease Cell Reports · 2025 · 4 citations
    16. Effective Role of Cytotoxic CD8+ T Cell in Iraqi Alopecia areata Patients Medical Journal of Babylon · 2024 · 2 citations
    17. Comparison between the effectiveness of topical Latanoprost and topical Minoxidil in treating Scalp Alopecia Areata in relation to CD8 cell expression: A study using clinical, dermoscopic, and immunohistochemical methods Jordan Journal of Applied Science - Natural Science Series · 2023 · 1 citations
    18. High throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in Alopecia Areata immuneACCESS · 2018 · 1 citations
    19. CD8 T cells require IFNg to induce disease in a murine model of Alopecia Areata 2310132 The Journal of Immunology · 2026
    20. 042 Characterization of Pathogenic CD8+ T Cells in an adoptive transfer Mouse Model of Alopecia Areata in C3H/HeJ mice Journal of Investigative Dermatology · 2025
    21. The function of BST2 in γδ T Cells, CD8 T Cells, and macrophages in alopecia areata pathogenesis 4231 The Journal of Immunology · 2025
    22. Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature bioRxiv (Cold Spring Harbor Laboratory) · 2025
    23. Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia Journal of Inflammation Research · 2025
    24. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes Journal of Investigative Dermatology · 2024
    25. 039 Expansion of regulatory T Cells restrains pathogenic CD8 T Cells in a murine model of alopecia areata Journal of Investigative Dermatology · 2024
    26. 452 Braicitinib treatment reduced the expansion of CD8+ T cells in C3H mice with skin grafts-induced alopecia areata Regular and Young Investigator Award Abstracts · 2023
    27. Generation of autoreactive CD8 T cell in a mouse model of alopecia areata The Journal of Immunology · 2023
    28. ISID1373 - Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata 2023
    29. 586 Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata Journal of Investigative Dermatology · 2023
    30. 1373 Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata Journal of Investigative Dermatology · 2023