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Glossary Immune Cell

Immune cells are specialized cells within the immune system that play a crucial role in defending the body against pathogens and foreign substances. In the context of hair loss, certain immune cells, such as T cells, can mistakenly target hair follicles, leading to conditions like alopecia areata, where hair is lost in patches due to an autoimmune response. Key distinguishing characteristics of immune cells include their ability to recognize and respond to antigens, as well as their diverse types, including lymphocytes, macrophages, and dendritic cells, each with specific functions in immune regulation and response. Understanding the role of immune cells in hair biology is essential for developing targeted therapies for autoimmune-related hair loss conditions.

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Research

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research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

253 citations , December 2007 in “Journal of Investigative Dermatology”

This study suggests that human hair follicles may actively suppress natural killer cells, which contrasts with the observed defects in NK cell regulation in alopecia areata.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations , August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

research Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

97 citations , May 2019 in “Frontiers in Cell and Developmental Biology”

This review examines the interaction between the extracellular matrix and immune cells in skin diseases and evaluates advanced therapies that target involved molecular mechanisms, reporting no new clinical findings.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures

61 citations , September 2010 in “Genomics”

This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.

research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

53 citations , September 2013 in “Journal of Investigative Dermatology”

This study suggests that cultured hair follicle dermal sheath cup cells exhibit immune privilege properties, partly through the expression of PD-L1, which impacts co-cultured immune cells' behavior.

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Community Join

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community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

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Learn

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learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

How does Osteopontin support the scalp’s healing and reduce inflammation? Osteopontin aids scalp healing by attracting immune cells and promoting growth factors.

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn procapil

Tried everything and still getting bald patches? Procapil may help calm the immune response Procapil is a cosmetic ingredient complex; laboratory studies of its individual ingredients report anti-inflammatory effects, but no published clinical trial has tested it in alopecia areata or any other immune-related hair loss. Spreading bald patches should be assessed by a dermatologist.

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