July 2023 in “Journal of the Mexican chemical society” This study found that Hibiscus rosa-sinensis dried leaves extract displayed the strongest pancreatic lipase inhibitory activity among 37 tested plant extracts, showing potential as an anti-obesity agent with effects comparable to the pharmaceutical drug orlistat in reducing plasma triacylglycerol levels in rats.
January 2026 in “Dermatology Research and Practice” This study found that ex vivo, the skin permeability of caffeine increased with formulations using natural caffeine from coffee extract, particularly when combined with 2.5% Transcutol P, compared to synthetic caffeine formulations.
6 citations
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March 2024 in “Saudi Pharmaceutical Journal” This study found that a nano-cubosome formulation co-loaded with capsaicin and thiocolchicoside enhanced bioavailability and showed promising analgesic and anti-inflammatory effects in rats, potentially benefiting gout management through improved transdermal delivery.
In this study, human dermal papilla cells exposed to wasabi leaf extract showed changes in cytokine-related gene expression, which the authors suggest could help clarify the biological effects of wasabi.
In a study on mice, the addition of 100 µM zinc to green papaya extract significantly improved wound healing and hair regrowth compared to other treatments, without causing inflammation.
June 2026 in “International Journal of Drug Delivery Technology” In this study using fertilized chicken eggs, researchers reported that ethanol and aqueous extracts of clove, cinnamon, and coriander significantly reduced blood vessel formation, indicating these herbs' potential as safe anti-angiogenic treatments without severe side effects compared to synthetic drugs.
October 2024 in “AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584)” This study found that a hair tonic made with 30% ethanol extract from papaya fruit peel effectively promoted hair growth in guinea pigs, with results close to those of a positive control, and contains beneficial compounds like alkaloids and flavonoids.
In this study, topical application of piperonylic acid was observed to accelerate wound healing in mice by enhancing EGFR activation, keratinocyte modulation, and collagen deposition, suggesting its potential as a treatment for skin injuries.
7 citations
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January 2021 in “Food & Function” In this animal study, Castanea sativa Mill. flower extract did not significantly affect prostate tumorigenesis but demonstrated antioxidant and anti-inflammatory effects on the prostate and liver.
July 2023 in “Research journal of pharmacy and technology” In this study on male rabbits, a hair tonic formulated with delipidated ethanol extract of Capsicum frutescens L. leaves at concentrations of 5%, 10%, and 20% promoted hair growth more effectively than a placebo and similar to 2% Minoxidil at the highest concentration.
2 citations
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December 2018 in “Natural Product Research” This study identified a new compound from fermented Carica papaya L. with moderate antioxidant and potent hair growth-stimulating activities in vitro.
8 citations
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February 2022 in “Molecules” This study found that Asparagus racemosus root extract significantly reduced facial sebum production and pore size in male volunteers, suggesting potential application as an anti-sebum ingredient in cosmetics.
1 citations
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October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products” This study found that methanolic extract of Ficus carica leaves induced apoptosis and inhibited proliferation in B16F10 melanoma cells, suggesting potential anti-cancer properties for further investigation in melanoma.
In this case report, interferon-alpha treatment for a man with hemophilia and hepatitis C was associated with unexpected diffuse hair growth, likely caused by the medication.
January 2023 in “Acta medica Philippina” This study found that ethyl acetate extract of Carica papaya flowers exhibited the highest antioxidant and 5α-reductase inhibitory activities, suggesting potential hair growth-promoting properties.
1 citations
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July 2025 in “Functional Foods in Health and Disease” This study found that supplementation with CL22209, a standardized Asparagus racemosus root extract, significantly reduced menopausal symptoms and improved hormonal regulation among early perimenopausal women, with notable improvements in vasomotor and menstrual symptoms compared to placebo, while being safe and well-tolerated over 120 days.
September 2024 in “Ahmar Metastasis Health Journal” In this study on Wistar rats, ginger and celery extracts at the tested dosage did not significantly affect hair growth onset, duration, or regrowth, nor did they cause significant inflammation, despite the presence of bioactive phytochemicals in the extracts.
January 2013 in “วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS)” This study found that ethyl acetate extract from mangosteen pericarp exhibited the strongest antibacterial effect against Propionibacterium acnes compared to other extraction solvents.
5 citations
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February 2019 in “Journal of oceanology and limnology (Online)” This study found that adding 7% Ecklonia cava extract to oxidative hair dyes significantly reduced their cytotoxicity and oxidative stress without affecting color performance.
1 citations
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January 2014 This study found that Crataegus pinnatifida extract promoted hair growth in mice by inducing the anagen phase, potentially through activating signaling pathways that enhance cell survival.
5 citations
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March 2023 in “Journal of Cosmetic Dermatology” This study reports that Plantago asiatica L. extract may promote hair growth by enhancing growth factor production and activating specific signaling pathways in hair follicle dermal papilla cells.
1 citations
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April 1986 in “The Journal of Dermatology” This study found that a topical plant worm extract significantly accelerated hair regrowth in mice without apparent toxicity or side effects.
39 citations
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December 2013 in “Phytotherapy Research” This study found that hydroxysafflor yellow A-rich Carthamus tinctorius extract promoted hair growth and gene expression linked to hair proliferation in both cell cultures and mouse models.
April 2023 in “Biomedical Journal of Scientific and Technical Research” In this study, researchers observed that Indian head cactus extract significantly increased the proliferation of human follicle dermal papilla cells and induced the expression of hair growth-related genes, suggesting its potential as a new therapy for promoting hair growth.
4 citations
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October 2025 in “Molecules” This study concluded that extracts from fermented pumpkin peel and pulp, processed with Lactobacillus strains and kombucha, may serve as multifunctional cosmetic ingredients, offering antioxidant protection, anti-aging, and skin regeneration benefits by demonstrating cytoprotective effects and reducing inflammatory cytokines in cell assays.
10 citations
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January 2022 in “Journal of Research in Pharmacy” In this experimental study on Wistar albino rats, Cotinus coggygria leaf extract demonstrated potential as a treatment for burn-induced skin damage by reducing cytokine levels and promoting tissue healing.
1 citations
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October 2001 in “Journal of Wood Science” This study found that extracts from the fungus YL161, Agaricus blazei, and the bark of Camptotheca cuminata promoted dermal papilla cell growth more effectively than pentadecanoic acid, suggesting potential for stimulating hair growth.
January 2003 in “Linchuang pifuke zazhi” In this study, Zingiber coralliaum oil induced premature hair growth in mouse skin during tests, suggesting its potential for managing hair growth disorders.
October 2024 in “Jurnal Pharmascience” This study concluded that formulations of celery and candlenut extracts meet the necessary criteria for use as a spray preparation aimed at promoting hair growth, based on evaluations of physical properties and consistency.
1 citations
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March 2022 in “The Scientific World Journal” This study found that a hair cream made from cocoa pod peel water fraction effectively stimulated hair growth in rabbits, with the best result at a 12.5% concentration, without causing skin irritation.