A Nanocomposite Competent to Overcome Solubility and Permeation Issues of Capsaicin and Thiocolchicoside Simultaneously in Gout Management: Fabrication of Nanocubosomes

The study developed nanocubosomes (NCs) to improve the solubility and permeation of capsaicin and thiocolchicoside for gout management. Using a Box-Behnken design, the researchers optimized the formulation, achieving a particle size of 206-503 nm and high entrapment efficiency. The NCs demonstrated stability, enhanced drug release, and significant anti-inflammatory and analgesic effects in animal models, with no skin irritation observed. This transdermal delivery system offers a promising alternative to oral therapy, enhancing the bioavailability and efficacy of these drugs in treating gout.