A Nanocomposite Competent to Overcome Solubility and Permeation Issues of Capsaicin and Thiocolchicoside Simultaneously in Gout Management: Fabrication of Nanocubosomes

This study developed nano-cubosomes co-loaded with capsaicin and thiocolchicoside to improve their bioavailability and reduce side effects through transdermal delivery. Using a Box-Behnken factorial design, 27 formulations were tested, with the optimized formulation showing a mean droplet size of 503 nm, a polydispersity index of 0.405, a zeta potential of -10.0 mV, and an entrapment efficiency of 86.9%. In vivo tests on rats demonstrated that the transdermal application significantly improved inflammation and analgesic effects compared to standard treatments. The study concludes that this delivery system could enhance the synergistic analgesic and anti-inflammatory effects of these compounds in gout management.