Effect of Transcutol P on Percutaneous Absorption of Gel Containing Pure Synthetic Caffeine or Plant-Extracted Natural Caffeine

    January 2026 in “ Dermatology Research and Practice ”
    Nastaran Seyyed Abbasi, Fatemeh Soltanmohammadi, Mohammad Charkhpour, Javad Shokri
    Studysummary This study found that ex vivo, the skin permeability of caffeine increased with formulations using natural caffeine from coffee extract, particularly when combined with 2.5% Transcutol P, compared to synthetic caffeine formulations.
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    Research cited in this study 3

    1. Transepidermal UV Radiation of Scalp Skin Ex Vivo Induces Hair Follicle Damage That Is Alleviated by Topical Treatment with Caffeine International Journal of Cosmetic Science · 2019
    2. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012
    3. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007