Skin Penetration of Caffeine and Cafestol Using Liposomes: Exploring the Benefits of a Combined Delivery System

    January 2026 in “ AAPS PharmSciTech ”
    Nubul Albayati, Amitkumar Virani, Sesha Rajeswari Talluri, Bożena Michniak-Kohn
    Studysummary In this study, a novel liposomal formulation combining caffeine and cafestol significantly enhanced their penetration into human skin layers, with formulation F9 doubling caffeine and greatly increasing cafestol levels in the dermis, suggesting potential for improved topical delivery.
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    Research cited in this study 3

    1. Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    2. A Comprehensive Review on Invasomal Carriers Incorporating Natural Terpenes for Augmented Transdermal Delivery Future Journal of Pharmaceutical Sciences · 2022
    3. Liposomal Systems as Drug Delivery Vehicles for Dermal and Transdermal Applications Archives of Dermatological Research · 2011