Wasabi Leaf Extract Changes the Expression Levels of Cytokine Related Genes in Dermal Papilla Cells, Identified by the Whole Transcriptome

May 2025

Himari Matsusaka, Tadafumi Kato, Mayuko Nakai, Lanlan Bai, Hiroshi Tomita, Eriko Sugano, Taku Ozaki, Isao Okunishi, Tomokazu Fukuda

wasabi leaf extract 6-methylsulfinylhexyl isothiocyanate isosaponarin cytokine dermal papilla cells gene expression next-generation sequencing wasabi extract

TLDR Wasabi leaf extract affects gene expression in skin cells.

The study investigated the effects of wasabi leaf extract on gene expression in immortalized human dermal papilla cells using next-generation sequencing. It was found that wasabi leaf extract, particularly compounds like 6-methylsulfinylhexyl isothiocyanate (6-MSITC) and isosaponarin, can upregulate or downregulate the expression of cytokine-related genes. These findings enhance the understanding of the biological effects of wasabi leaf extract, which has previously been noted for its anti-proliferative effects on cancer cells and antibacterial properties.

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