Transcriptome Analysis to Identify the Downstream Genes of Androgen Receptor in Dermal Papilla Cells

January 2022 in “ BMC Genomic Data ”

Kai Furuya, So Fujibayashi, Tao Wu, Kazumasa Takahashi, Shin Takase, Ai Orimoto, Eriko Sugano, Hiroshi Tomita, Sayo Kashiwagi, Tohru Kiyono, Tsuyoshi Ishii, T. Fukuda

androgen receptor dermal papilla cells testosterone signaling androgenetic alopecia focal adhesion pathway caveolin-1 EGFR AR signaling EGF signals AR hair loss male pattern baldness epidermal growth factor receptor

Studysummary In this study, researchers found that androgen receptor activation in dermal papilla cells mainly affected the focal adhesion pathway and downregulated caveolin-1 gene expression, which could help identify new therapeutic targets for testosterone-related diseases.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on bmcgenomdata.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

8 citations , March 2020 in “Frontiers in Cell and Developmental Biology”

This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.

research Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects

41 citations , January 2009 in “International Journal of Trichology”

This study found that 58% of men aged 30-50 had androgenic alopecia, with disease severity increasing with age and many being candidates for medical treatment or hair transplantation.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.