Carica Papaya Flower Extracts Possess Antioxidant and 5α-Reductase Inhibitory Activities

    January 2023 in “ Acta medica Philippina ”
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    TLDR Papaya flower extract may help with hair growth by blocking a hair loss enzyme and acting as an antioxidant.
    The study investigated the effects of various extracts of Carica papaya flower on hair loss-related biological activities, including 5α-reductase inhibition and antioxidation. The flowers were macerated with ethanol, ethyl acetate, and hexane to obtain crude extracts, which were then subjected to antioxidant tests and 5α-reductase inhibition tests. The ethyl acetate extract showed significantly higher antioxidant activity and 5α-reductase inhibitory activity compared to the other extracts. It also had the highest total phenolic and flavonoid contents. Forty-nine compounds were found in the ethyl acetate extract, with seven identified as potentially beneficial for hair growth. The results suggest that local C. papaya flowers could be a source of hair growth-promoting agents due to their antioxidant and 5α-reductase inhibitory potential.
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