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Radiation treatment causes skin fibrosis by increasing certain fibroblast subpopulations, but using a c-Jun inhibitor or fat grafting can reduce this effect.

PROTO1 and PROTO2 protect against hearing damage.

Researchers identified five new potential targets for leishmaniasis treatment, suggesting repurposing existing drugs could be effective.

DA-9401 helps protect rat testis from finasteride damage.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

Applying a specific inhibitor lightens skin and hair color.

Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.

Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Enzymes play crucial roles in metabolism, health, and disease management.

Centipeda minima extract helps hair grow by activating important growth signals and could be a promising hair loss treatment.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Vitamin C helps adipose-derived stem cells grow and may support hair growth.

Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Targeted therapies for lung cancer are effective but require careful management of side effects to benefit patients.

The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

Scalp cooling to prevent hair loss from chemotherapy works for some but not all, and studying hair damage markers could improve prevention and treatment.

Gray hair can potentially be reversed, leading to new treatments.

UV radiation may cause DNA changes in skin, certain UVB therapy helps psoriasis, a new gene mutation is linked to mild piebaldism, different immune cells affect psoriasis, a drug promotes hair growth, and some cancer drugs could treat skin barrier issues.