March 2013 in “Hair transplant forum international” Inflammation linked to the immune response may play a role in causing various types of hair loss.
45 citations
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June 2018 in “Frontiers in immunology” MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.
39 citations
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October 2012 in “Familial cancer” New therapies for Birt–Hogg–Dubé syndrome are being developed based on understanding the FLCN gene's role.
11 citations
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October 2021 in “Orphanet journal of rare diseases” Patients with RASopathies are at risk for autoimmune disorders and should be routinely screened.
5 citations
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January 2016 in “Skin appendage disorders” Frontal fibrosing alopecia might be linked to autoimmune diseases.
5 citations
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May 2021 in “EMBO journal” Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
3 citations
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July 2023 in “Biomolecules” B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.
3 citations
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June 2023 in “Molecules/Molecules online/Molecules annual” Cepharanthine has many medicinal uses but needs improvement for better effectiveness.
2 citations
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September 2022 in “Frontiers in Immunology” T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
1 citations
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December 2023 in “iScience” A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.
Tofacitinib may effectively treat hair loss and improve symptoms in autoimmune conditions like alopecia areata and Sjögren's syndrome, but long-term treatment might be necessary.
489 citations
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November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
143 citations
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May 2017 in “Nature cell biology” Wounded skin cells can revert to stem cells and help heal.
113 citations
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June 2019 in “F1000Research” Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.
39 citations
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September 2007 in “BMC developmental biology” Neuregulin3 affects cell development in the skin and mammary glands.
38 citations
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June 2019 in “International Journal of Women's Dermatology” The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
38 citations
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April 2017 in “PLOS Genetics” GRHL3 is important for controlling gene activity in skin cells during different stages of their development.
37 citations
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December 2021 in “Cells” Alopecia areata severity and treatment response are linked to specific cytokine levels.
36 citations
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December 2014 in “F1000 prime reports” The document concludes that Hidradenitis suppurativa is often underdiagnosed, lacks definitive treatment, and requires better awareness and management strategies.
31 citations
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August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
25 citations
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December 2021 in “Stem Cell Research & Therapy” MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.
21 citations
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June 2009 in “Mammalian genome” A new mutation in the Hr gene causes hair loss in mice, similar to a human hair disorder.
20 citations
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August 2022 in “Frontiers in Immunology” Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.
13 citations
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April 2019 in “International journal of molecular sciences” Acyzol could help treat conditions caused by zinc deficiency.
12 citations
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September 2022 in “Foods” Some nutraceuticals may help in COVID-19 prevention and treatment, but more research is needed.
11 citations
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November 2021 in “Anais Brasileiros de Dermatologia” The conclusion is that early diagnosis of skin signs linked to diseases like Lupus, Dermatomyositis, and Rheumatoid Arthritis is crucial to prevent serious complications.
10 citations
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August 2023 in “Advanced Science” Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.
9 citations
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May 2021 in “Frontiers in Cell and Developmental Biology” DNA methylation changes in women with PCOS could be used as disease markers and suggest new treatment targets.
8 citations
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June 2023 in “Journal of clinical medicine” Nanofat shows promise for facial rejuvenation and treating skin issues but needs more research for long-term safety.
6 citations
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May 2022 in “Biomedicine & pharmacotherapy” Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.