Case of Alemtuzumab-Related Alopecia Areata Management in Multiple Sclerosis

October 2018 in “ Neurology Neuroimmunology & Neuroinflammation ”

Jillian Chan, Anthony Traboulsee, Ana‐Luiza Sayao

alemtuzumab alopecia areata intralesional corticosteroids methylprednisolone systemic corticosteroids AA steroids

TLDR Systemic corticosteroids might help treat hair loss caused by alemtuzumab in MS patients.

A 31-year-old woman with relapsing-remitting MS developed alopecia areata (AA) after her second course of alemtuzumab treatment. Despite initial treatment with intralesional corticosteroids, significant hair loss continued. However, following an acute MS relapse treated with intravenous methylprednisolone, she experienced rapid and complete hair regrowth. This case highlighted a potential temporal link between alemtuzumab and AA, suggesting that systemic corticosteroids might be effective for treating alemtuzumab-related AA. Long-term follow-up was recommended to assess hair regrowth and recurrence risk.

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