Deficient and/or Insufficient Serum 25 Hydroxy Vitamin D in Patients with Alopecia Areata: Is It a Fact or Fiction?
TLDR Low vitamin D levels might indicate more severe hair loss in alopecia areata patients.
The study conducted five years ago involved 20 patients with mild to moderate Alopecia Areata (AA) and 20 healthy individuals as controls. The researchers found that serum 25 hydroxy vitamin D [25(OH)D] levels were significantly lower in the AA group compared to the control group. However, within the AA group, there were no significant differences in serum 25(OH)D levels, suggesting that vitamin D deficiency and/or insufficiency may not be a predominant cause of inducing or enhancing autoimmunity in patients with AA. The study also found a significant negative correlation between serum 25(OH)D levels and Severity of Alopecia Tool (SALT) scores in the AA group, indicating that deficient serum 25(OH)D may be a marker of increased severity of AA.
