Inactivated COVID-19 Vaccine Induces a Low Humoral Immune Response in a Subset of Dermatological Patients Receiving Immunosuppressants

    December 2021 in “ Frontiers in Medicine ”
    Chutima Seree-aphinan, Kumutnart Chanprapaph, Ploysyne Rattanakaemakorn, Chavachol Setthaudom, Thanitta Suangtamai, Cherrin Pomsoong, Yanisa Ratanapokasatit, Poonkiat Suchonwanit
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    TLDR Some patients on immunosuppressants had a weaker immune response to the Sinovac-CoronaVac COVID-19 vaccine.
    The study conducted on 32 dermatological patients found that the Sinovac-CoronaVac COVID-19 vaccine induced a lower humoral immune response in patients receiving certain systemic immunosuppressive therapies compared to those who did not. All participants developed anti-SARS-CoV-2 IgG antibodies, but those on certain immunosuppressants had lower neutralizing antibody levels and seroconversion rates. However, patients on low-dose methotrexate, low-dose systemic corticosteroids, or biologics showed a better immune response. The study suggests that the type of immunosuppressive therapy and the patient's comorbidities influence the immune response to the vaccine. No participants developed symptomatic COVID-19 during a 3-month follow-up. The study did not assess the cellular immune response and had a small sample size, indicating the need for further research.
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