Inactivated COVID-19 Vaccine Induces a Low Humoral Immune Response in a Subset of Dermatological Patients Receiving Immunosuppressants
December 2021
in “
Frontiers in Medicine
”
dermatological patients immunosuppressants systemic immunosuppressive therapies anti-SARS-CoV-2 IgG antibodies neutralizing antibody levels seroconversion rates methotrexate systemic corticosteroids biologics skin patients immune suppressants immune system suppressing treatments COVID-19 antibodies neutralizing antibodies conversion rates MTX steroids biological drugs
TLDR Some patients on immunosuppressants had a weaker immune response to the Sinovac-CoronaVac COVID-19 vaccine.
The study conducted on 32 dermatological patients found that the Sinovac-CoronaVac COVID-19 vaccine induced a lower humoral immune response in patients receiving certain systemic immunosuppressive therapies compared to those who did not. All participants developed anti-SARS-CoV-2 IgG antibodies, but those on certain immunosuppressants had lower neutralizing antibody levels and seroconversion rates. However, patients on low-dose methotrexate, low-dose systemic corticosteroids, or biologics showed a better immune response. The study suggests that the type of immunosuppressive therapy and the patient's comorbidities influence the immune response to the vaccine. No participants developed symptomatic COVID-19 during a 3-month follow-up. The study did not assess the cellular immune response and had a small sample size, indicating the need for further research.
