Humoral Immune Response to COVID-19 Vaccination in Psoriasis Patients on Biologic Therapy Is Impaired Compared to Healthy Controls

    April 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    H. Puschmann, W. Milz, S. Emmert, R. Panzer
    Image of study
    TLDR Psoriasis patients on biologic therapy have a weaker immune response to COVID-19 vaccination than healthy people.
    The study investigated the humoral immune response to COVID-19 vaccination in psoriasis patients undergoing biologic therapy compared to healthy controls. Blood samples were collected 4 to 8 weeks after the second vaccination dose, and IgG and IgA antibody titers were measured using ELISA analysis. The psoriasis group included patients treated with IL-17 inhibitors, IL-23 inhibitors, and TNF alpha inhibitors. Results indicated that psoriasis patients on biologic therapy had significantly lower anti-COVID-19 IgG antibody titers compared to healthy controls. These findings suggest that vaccination recommendations may need adjustment for immunosuppressed patients.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 148 results

      community Average r/bald user complaining

      in Satire  398 upvotes 1 month ago
      Hair loss treatments like Minoxidil, finasteride, and RU58841, focusing on their effectiveness and side effects. It also highlights the disparity in medical research funding between hair loss and conditions like endometriosis.

      community Hair Loss “Cure” for Inflammation: Topical Roflumilast

      in Research/Science  31 upvotes 3 days ago
      Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

      community 8 years of hair loss, turning 30 next month

      in Progress Pictures  152 upvotes 6 months ago
      The user has been dealing with hair loss for 10 years, worsened by psoriasis, and uses minoxidil and finasteride. They seek advice on managing psoriasis and hair loss, with suggestions to see a dermatologist, try different shampoos, and be patient.

      community Scalp Psoriasis and Fin/Min options?

      in Treatment  3 upvotes 1 week ago
      A user with scalp psoriasis and hair loss is hesitant to use topical minoxidil and finasteride due to concerns about psoriasis and potential side effects. They are considering alternatives like pumpkin seed and saw palmetto.

    Similar Research

    5 / 1000+ results