TLDR Vitamin D3 is important for bone health and may help treat various diseases beyond bone-related conditions.
The document discussed the essential role of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in maintaining bone health and its broader noncalcemic actions, such as acting as an antiproliferative and prodifferentiation mediator in various tissues. It highlighted the hormone's clinical applications in treating rheumatoid and psoriatic arthritis, type I diabetes, hypertension, cardiac arrhythmias, seizure disorders, certain cancers, chemotherapy-induced hair loss, and skin diseases like psoriasis and ichthyosis, emphasizing its diverse therapeutic potential beyond calcium metabolism.
70 citations,
November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
26 citations,
March 2014 in “Journal of cutaneous medicine and surgery” Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.
9 citations,
June 2023 in “Cells” Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.
120 citations,
February 2009 in “Apoptosis” Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
11 citations,
June 1996 in “Nutrition” Vitamin D3 may prevent hair loss from chemotherapy, but side effects and cancer cell protection are concerns.
48 citations,
February 2017 in “Journal of Cosmetic Dermatology” The conclusion is to use scalp cooling, gentle hair care, and treatments like minoxidil for managing hair loss from chemotherapy, and stresses the need for more research and collaboration in this area.
