Noncalcemic Actions of 1,25-Dihydroxyvitamin D3 and Clinical Applications
August 1995
in “
Bone
”
TLDR Vitamin D3 is important for bone health and may help treat various diseases beyond bone-related conditions.
The document discussed the essential role of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in maintaining bone health and its broader noncalcemic actions, such as acting as an antiproliferative and prodifferentiation mediator in various tissues. It highlighted the hormone's clinical applications in treating rheumatoid and psoriatic arthritis, type I diabetes, hypertension, cardiac arrhythmias, seizure disorders, certain cancers, chemotherapy-induced hair loss, and skin diseases like psoriasis and ichthyosis, emphasizing its diverse therapeutic potential beyond calcium metabolism.
