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The PW91 method is best for calculating the basic physical and chemical properties of Finasteride, a drug used for prostate issues and hair loss.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Finasteride safely lowers DHT levels without affecting testosterone.

Finasteride effectively treats baldness but may cause sexual side effects.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

Four-amino acid part makes enzyme sensitive to finasteride.

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Different forms of hair loss drug can improve effectiveness.

Both drugs lower DHT levels, with GI198745 being more effective.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Certain drugs that block specific enzymes can help treat prostate diseases.

Finasteride effectively treats hirsutism in women, but more research needed for long-term results.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Method detects finasteride in plasma and semen with high sensitivity and accuracy.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.