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    Glossary 4-azasteroid

    synthetic compound mimicking steroids with a nitrogen atom

    A 4-azasteroid is a type of synthetic compound that mimics the structure of steroids but includes a nitrogen atom at the fourth position in its chemical structure. These compounds are often used in medical treatments to inhibit enzymes like 5-alpha-reductase, which can help manage conditions such as benign prostatic hyperplasia and androgenic alopecia (hair loss).

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    Research 30 of 169

    1. Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin 1993 · 34 citations
    2. Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones 2016
    3. Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes Molecules · 2011 · 186 citations
    4. 13C-NMR study of 4-azasteroids in solution and solid state Steroids · 2002 · 25 citations
    5. Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids Steroids · 2015 · 13 citations
    6. Synthesis of a 4-azasteroid hormones compound Xiandai huagong · 2009
    7. An overview on 5α-reductase inhibitors Steroids · 2009 · 219 citations
    8. Recent advances in thiasteroids chemistry Steroids · 2006 · 37 citations
    9. Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase Bioorganic & Medicinal Chemistry · 1997 · 5 citations
    10. 12 Treatment of hirsutism with 5α-reductase inhibitors Clinics in endocrinology and metabolism · 1986 · 28 citations
    11. 5α‐Reductase inhibitors and prostatic disease Clinical endocrinology · 1994 · 21 citations
    12. Novel inhibitors of 5α-reductase Expert Opinion on Therapeutic Patents · 2002 · 20 citations
    13. 5α-Reductase Inhibitors, Chemical and Clinical Models Steroids · 1998 · 17 citations
    14. A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis Journal of proteome research · 2008 · 14 citations
    15. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    16. A concise review- Development of an analytical method and validation of dutasteride Current Trends in Pharmacy and Pharmaceutical Chemistry · 2025
    17. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003 · 42 citations
    18. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017 · 27 citations
    19. Alopecia - the search for novel agents continues Expert Opinion on Therapeutic Patents · 1997 · 11 citations
    20. Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor. PubMed · 1995 · 7 citations
    21. Species Differences in Prostatic Steroid 5<i>α</i>-Reductases of Rat, Dog, and Human Endocrinology · 1985 · 193 citations
    22. FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS Universal journal of pharmaceutical research · 2016 · 3 citations
    23. FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA e-Jurnal Medika Udayana · 2013
    24. Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation Analytica Chimica Acta · 2006 · 11 citations
    25. High-performance liquid chromatographic method for the determination of finasteride in human plasma at therapeutic doses Journal of Chromatography B: Biomedical Sciences and Applications · 1991 · 19 citations
    26. Dutasteride: A Review of its Use in the Management of Prostate Disorders Clinical medicine insights · 2011 · 2 citations
    27. EVALUATING HISTOLOGICAL MODIFICATIONS OF TESTIS AND SPERMATOGENESISIN ADULT MALE RATS ON FINASTERIDE Journal of Reproduction & Infertility · 2007
    28. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    29. New 5?-reductase inhibitors: In vitro and in vivo effects Steroids · 2005 · 45 citations
    30. Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor. Chemical & Pharmaceutical Bulletin · 2001 · 23 citations