Search

for
Search:

Did you mean 4-azasteroid?

Glossary 4-azasteroid

synthetic compound mimicking steroids with a nitrogen atom

A 4-azasteroid is a type of synthetic compound that mimics the structure of steroids but includes a nitrogen atom at the fourth position in its chemical structure. These compounds are often used in medical treatments to inhibit enzymes like 5-alpha-reductase, which can help manage conditions such as benign prostatic hyperplasia and androgenic alopecia (hair loss).

Related Terms

Sort by

Research

30 / 1000+ results

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.

research Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones

December 2016

This review explores the synthesis and potential of azasteroids as novel drugs, discussing challenges in their production and reporting no new clinical results.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

This study examined 4-azasteroids using 13C-NMR spectroscopy, detailing the NMR spectrum assignments and reporting a new molecular complex of finasteride with dioxane.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.

research Synthesis of a 4-azasteroid hormones compound

January 2009 in “Xiandai huagong”

This research outlines a chemical synthesis process for Finasteride, detailing the conversion of pregnadienolone acetate through various chemical reactions and modifications.

research An overview on 5α-reductase inhibitors

219 citations , October 2009 in “Steroids”

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

research Recent advances in thiasteroids chemistry

37 citations , October 2006 in “Steroids”

This paper describes recent advancements in the synthesis of thiasteroids but reports no new experimental results, noting that introducing heteroatoms in steroidal structures has potential biological effects.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

This study found that newly synthesized steroidal trienones demonstrated stronger 5α-reductase inhibitory activity compared to dienones in various biological models, suggesting potential for developing enhanced antiandrogenic drugs.

research 12 Treatment of hirsutism with 5α-reductase inhibitors

28 citations , May 1986 in “Clinics in endocrinology and metabolism”

This review discusses the potential of 4-azasteroids as 5α-reductase inhibitors for treating hirsutism, reporting their promising effects in animal studies but noting no clinical trials have been conducted yet.

research 5α‐Reductase inhibitors and prostatic disease

21 citations , August 1994 in “Clinical endocrinology”

This article reviews the effects of 5 alpha-reductase inhibitors for treating conditions like male pattern baldness and benign prostatic hyperplasia, noting significant DHT reduction but reports no new clinical results.

research Novel inhibitors of 5α-reductase

20 citations , February 2002 in “Expert Opinion on Therapeutic Patents”

This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.

research 5α-Reductase Inhibitors, Chemical and Clinical Models

17 citations , May 1998 in “Steroids”

This study constructed a model to predict finasteride's inhibitory activity on 5α-reductase type 2 and calculated that a 1 μM plasma concentration, after 50 mg administration, matches prostate inhibition levels.

research A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

14 citations , May 2008 in “Journal of proteome research”

This study found that dutasteride reduced β-amyloid plaque load in a cerebral amyloidosis model, seemingly linked to mitochondrial apoptosis and autophagy processes.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

research A concise review- Development of an analytical method and validation of dutasteride

January 2025 in “Current Trends in Pharmacy and Pharmaceutical Chemistry”

This review examines recent advancements in analytical techniques used to quantify dutasteride, a medication for enlarged prostate, in various biological samples and its commercial forms, emphasizing methods such as HPTLC, GC-MS, and HPLC.

research Dutasteride in Androgenetic Alopecia: An Update

27 citations , March 2017 in “Current Clinical Pharmacology”

In this review, the authors discuss the pharmacology of dutasteride and compare its efficacy to finasteride for treating androgenetic alopecia, highlighting dutasteride's effectiveness demonstrated in several clinical trials.

research Alopecia - the search for novel agents continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.

research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.

7 citations , July 1995 in “PubMed”

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

This study found significant species differences in the enzyme activity and inhibitor affinities of prostatic 5α-reductases from rats, dogs, and humans, with variable potencies for different 3-oxo-4-azasteroid inhibitors across species.

research FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

3 citations , December 2016 in “Universal journal of pharmaceutical research”

This study concluded that Finasteride can be effectively delivered in matrix tablets using different polymer ratios for sustained release.

research FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

April 2013 in “e-Jurnal Medika Udayana”

This abstract indicates that finasteride, at a dose of 1 mg per day, is effective in treating androgenetic alopecia in men by significantly reducing DHT levels.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

This study identified novel compounds as selective inhibitors of the type 1 isoenzyme of 5α-reductase, displaying promising potential for treating DHT-dependent disorders such as acne and androgenic alopecia.

research Finasteride: The First 5α-Reductase Inhibitor

23 citations , July 1993 in “Pharmacotherapy”

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia

52 citations , February 2006 in “Current pharmaceutical design”

This review discusses the use of 5α-reductase inhibitors in treating benign prostatic hyperplasia, highlighting their long-term effectiveness and benefits when combined with α1-adrenergic antagonists; it reports no new clinical results.

Determination of Finasteride in Tablet Form by Liquid Chromatography and Its Analytical Method Validation

research Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation

11 citations , January 2006 in “Analytica Chimica Acta”

Validated method reliably measures finasteride in tablets using liquid chromatography.

research 5α-Reductase Inhibitors – The Finasteride Story

3 citations , October 2010 in “Wiley-VCH Verlag GmbH & Co. KGaA eBooks”

Finasteride safely treats enlarged prostate and male-pattern baldness.

research High-performance liquid chromatographic method for the determination of finasteride in human plasma at therapeutic doses

19 citations , May 1991 in “Journal of Chromatography B: Biomedical Sciences and Applications”

This study developed and validated an HPLC method for detecting a novel 5α-reductase inhibitor in human plasma, supporting its pharmacokinetic evaluation at low doses.

research Dutasteride: A Review of its Use in the Management of Prostate Disorders

2 citations , January 2011 in “Clinical medicine insights”

The authors concluded that dutasteride is effective and generally safe for managing benign prostatic hyperplasia and may reduce prostate cancer risk.