31 citations
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August 2015 in “Stem Cells Translational Medicine” This review discusses autologous dermis-derived stem cells and their potential in regenerative medicine, summarizing current literature on their niches, characteristics, and applications, but it reports no new experimental results.
23 citations
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November 2019 in “International Journal of Molecular Sciences” This study found that adipose-derived stem cells from HIV-infected patients with lipodystrophy associated with HAART demonstrated similar growth and differentiation potential as those from HIV-uninfected patients, suggesting potential for autologous regenerative therapy.
20 citations
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May 2015 in “Regenerative Medicine” This commentary explores the marketing of unproven and unlicensed adipose-derived stem cell treatments in US clinics, highlighting concerns about patient safety and regulatory challenges.
17 citations
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March 2021 in “Expert Opinion on Biological Therapy” This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.
September 2024 in “British journal of surgery” In this study, autologous stem cell therapy was associated with a 29% increase in hair density in androgenetic alopecia patients over six months, suggesting potential for further investigation.
July 2024 in “British journal of surgery” This review reports that regenerative medicine, such as autologous stem cell micrografting and Rigenera®, may significantly improve hair density in individuals with androgenetic alopecia, highlighting its potential as a future therapeutic option that addresses current treatment limitations.
February 2024 in “Plastic and Reconstructive Surgery – Global Open” This systematic review found that both cellular and acellular stem cell-based therapies are safe and able to improve hair regeneration and density in patients with androgenic alopecia, although some results may be temporary.
May 2019 in “Cytotherapy” This study explored how Australian patients and their carers perceived autologous stem cell interventions, highlighting factors like illness experience and unrealistic expectations that influenced their decision-making in an unregulated market.
December 2023 in “Journal of Asia Pacific Aesthetic Sciences” This study found that a novel method of isolating human follicle stem cells from hair follicles via mechanical centrifugation, without culture conditions, promises to improve hair density in patients with Androgenetic Alopecia and some cases of Alopecia Areata.
October 2024 in “Aesthetic Plastic Surgery” In this multicenter observational study, researchers found that using micrografts with human follicle mesenchymal stem cells increased hair density significantly in both male and female patients with mild to moderate androgenic alopecia after 12 months, suggesting a viable alternative for hair regrowth.
June 2023 in “Plastic and Reconstructive Surgery” In this study, autologous hair follicle mesenchymal stem cell therapy was effective in promoting hair growth in Chinese patients with advanced androgenic alopecia, particularly improving hair shaft diameter in follicles less than 60 µm without obvious side effects.
February 2026 in “Annals of dermatological science.” In this case report, two young women with female pattern hair loss experienced significant hair regrowth without adverse effects after six months of treatment with bone-marrow-derived mesenchymal stem cells and their extracellular vesicles, suggesting potential for this approach when conventional treatments fail.
June 2024 in “Дерматовенерология Косметология” In this study, treatment with autologous follicular stem cells improved hair conditions in 57% of patients with androgenic and telogen effluvium alopecia, as confirmed by phototrichograms, indicating its potential effectiveness for non-scarring alopecia.
July 2023 in “Journal of personalized medicine” This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.
January 2020 in “Journal of Genetics and Gene Therapy” This article discusses the potential use of human hair follicular stem cells combined with platelet-rich plasma for androgenetic alopecia, focusing on the regenerative processes involved, but reports no new clinical results.
88 citations
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July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
86 citations
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June 2017 in “Stem cell investigation” This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.
October 2021 in “QJM: An International Journal of Medicine” This study found that injection of adipose-derived adult stem cells improved hair density, thickness, and reduced inflammation in women with female pattern hair loss over 24 weeks.
March 2025 in “International Journal of Trichology” This study found that, in female patients with pattern hair loss, injections of adipose-derived stem cells increased hair density and thickness, reduced perifollicular inflammation, and enhanced markers associated with hair cycle regeneration.
2 citations
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January 2018 in “Journal of clinical & experimental dermatology research” This study suggests that AT-ASCs significantly improve terminal and intermediate hair counts and hair caliber in androgenetic alopecia more than PRP, though with more side effects like headache and erythema.
April 2018 in “Cytotherapy” This article reviews the potential of PRP and adipose-derived stem cell treatments for hair growth, but provides no new clinical results, calling for more research in these areas.
69 citations
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April 2019 in “Biomedicines” This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.
January 2024 in “Biomedicines” This study found that a single injection of autologous cell micrografts significantly improved hair condition in women with androgenetic alopecia six months post-treatment.
5 citations
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July 2023 in “Frontiers in Veterinary Science” This study found that wounds in sheep treated with mesenchymal stem cells and platelet-rich plasma showed improved healing, reduced inflammation and contraction, and better skin structure compared to untreated wounds.
2 citations
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December 2010 in “Zhonghua neifenmi daixie zazhi” This study found that autologous nonmyeloablative hematopoietic stem cell transplantation may help some newly-onset type 1 diabetes patients become insulin-free, although gastrointestinal and other mild side effects were observed.
419 citations
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March 2005 in “Proceedings of the National Academy of Sciences” This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.
87 citations
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June 2010 in “Stem Cell Research & Therapy” This study demonstrated that epidermal neural crest stem cells and bone marrow-derived stem cells migrated toward inflammatory brain lesions in rats and were successfully tracked using noninvasive MRI.
33 citations
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September 2008 in “Biochemical and Biophysical Research Communications” Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.
21 citations
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July 2020 in “Stem Cell Research & Therapy” This study found that adipose-derived mesenchymal stem cells from type 2 diabetes mice were slightly less effective, yet had comparable therapeutic effects on wound healing compared to non-diabetic controls.
5 citations
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May 2024 in “BMC Biotechnology” This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.