Successful Treatment of Female Pattern Hair Loss with Injection of Autologous Adipose-Derived Adult Stem Cells: A Controlled Clinical, Trichoscopic, and Immunohistochemical Trial

March 2025 in “ International Journal of Trichology ”

Hoda Moneib, Ghada Fathy, Naglaa Ahmed Samir, Nashwa El‐Khazragy, Mahy El‐Bassiouny

autologous adipose-derived stem cells female pattern hair loss trichoscopic immunohistochemical perifollicular inflammation follistatin DKK-1 ADSCs FPHL

TLDR Injecting stem cells from a patient's own fat can improve hair growth in women with hair loss.

This study investigated the effectiveness of autologous adipose-derived stem cells (ADSCs) injections for treating female pattern hair loss (FPHL) in a controlled trial with 33 patients. The ADSCs were extracted from the patients' own fat and injected into the scalp. Results at 12 and 24 weeks showed significant improvements in hair thickness, count, and density, along with a reduction in perifollicular inflammation. Additionally, there was an increase in the hair cycle stimulatory marker follistatin and a decrease in the suppressor marker DKK-1. The findings suggest that ADSCs can enhance hair cycle regeneration and improve hair growth in FPHL patients.

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