Successful Treatment of Female Pattern Hair Loss with Injection of Autologous Adipose-Derived Adult Stem Cells: A Controlled Clinical, Trichoscopic, and Immunohistochemical Trial

    March 2025 in “ International Journal of Trichology ”
    Hoda Moneib, Ghada Fathy, Naglaa Ahmed Samir … Mahy El‐Bassiouny
    Studysummary This study found that, in female patients with pattern hair loss, injections of adipose-derived stem cells increased hair density and thickness, reduced perifollicular inflammation, and enhanced markers associated with hair cycle regeneration.
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    Research cited in this study 13

    1. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    2. Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences Dermatologic Therapy · 2016
    3. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015
    4. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    5. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    6. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    7. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    8. Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls International Journal of Trichology · 2013
    9. Challenges in Diagnosing Female Pattern Hair Loss Journal of Cosmetic Dermatology · 2012
    10. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    11. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    12. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    13. The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit British Journal of Dermatology · 2008