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Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.

In this study, researchers observed that apoptosis occurs in both growing and regressing hair follicles in dogs, indicating a spatio-temporal relationship with the hair cycle.

In this study using live mice, researchers observed that during hair follicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.

This study in live mice suggests that hair follicle regression involves apoptosis propagation towards stem cells, potentially slowed by a protective signal from the stem cells themselves.

This study investigated the effects of cedrol on colorectal cancer and found that it inhibited cell proliferation and induced cell cycle arrest and apoptosis in cell models, while in vivo, it suppressed cancer progression and improved survival at a well-tolerated dose.

This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.

This study found that the fermented black soybean product GR-SC65 reduced particulate matter-induced cell death and oxidative stress in A549 cells, suggesting potential as a therapeutic agent for lung injury prevention.

This study found that GS-KG9 and GS-E3D, bioactive ginseng extracts, reduced BBB disruption and neuronal apoptosis in the hippocampus of diabetic rats, suggesting potential therapeutic effects for diabetic patients.

This study found that storing hair follicle micrografts in HEPES-buffered DMEM with ACD inhibitors like aminoguanidine significantly increased hair shaft elongation compared to phosphate-buffered salt solution, suggesting improved viability for transplantation.

This study found that storing hair micrografts in DMEM with apoptotic cell death inhibitors improved in vitro hair shaft elongation and reduced apoptosis, potentially enhancing micrograft transplantation outcomes.

This study found that diffuse alopecia in HIV-1-infected patients is characterized by higher rates of follicular stem cell apoptosis compared to controls, suggesting a hair cycle disturbance associated with the infection.

This study found that blocking apoptosis during the catagen phase in mice disrupts hair follicle stem cell niche architecture, delaying subsequent hair regeneration cycles.

This study suggests that cultured hair follicle dermal sheath cup cells exhibit immune privilege properties, partly through the expression of PD-L1, which impacts co-cultured immune cells' behavior.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This review discusses the mechanisms of skin-associated cell death and their potential role in treating inflammatory skin diseases, but presents no new clinical findings.

This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.

This study suggests that higher PDCD4 expression may play a significant role in polycystic ovary syndrome pathogenesis through its association with obesity, insulin resistance, lipid metabolism disorders, and increased granulosa cell apoptosis.

This study found that local PGE2 injection may prevent radiotherapy-induced hair loss by protecting hair follicle cells and promoting hair follicle self-repair.

This review examines the process of cornification as a mode of programmed cell death and outlines how keratinocytes activate anti-cell death mechanisms to maintain epidermal homeostasis, but reports no new results.

This study found that overexpression of the anti-apoptotic protein Bcl-2 in mice disrupted cell death during the hair cycle, impairing hair regeneration by delaying anagen entry and hair growth.

This study found that inhibiting allopregnanolone synthesis in late gestation fetal sheep increased apoptosis and dead cell count in the hippocampus and cerebellum, effects that were mitigated by alfaxalone co-infusion.

In this study, transcriptome analysis identified 68 differentially expressed miRNAs in human dermal papilla cells treated with hydrogen peroxide, suggesting they play a significant role in growth arrest and apoptosis.

This review discusses the basic biology of apoptosis and its relevance to skin diseases, without presenting new research findings.

This study demonstrated that an ethanol extract of Connarus semidecandrus Jack showed potential anti-androgenic alopecia effects in a testosterone-induced model, suggesting a possible treatment option for hair loss.

This review discusses how targeting apoptosis pathways in hair and skin cells can inform the development of novel therapies, but it reports no clinical findings.

This review highlights the importance of apoptosis in the hair cycle, particularly its role in hair follicle regression and loss, suggesting that understanding its mechanisms can aid in developing treatments to reduce hair loss and promote hair growth.

This review examines the life cycle, biomarkers, and functions of hair follicle stem cells, emphasizing their role in hair loss therapy and other skin and hair disorders, but reports no new clinical results.

Caffeine can damage hearing cells and affect hearing recovery after ear trauma.

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

This study found that in individuals with androgenetic alopecia, the expression of apoptosis-related markers differed significantly between affected and unaffected scalp areas.