Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

The research paper studied the anti-cancer potential of Cedrol, a natural compound found in Cedrus atlantica, on colorectal cancer (CRC). The study used both in vitro and in vivo models, specifically HT-29 and CT-26 cells. Results showed that Cedrol inhibited the growth of these cells in a time- and dose-dependent manner, induced cell cycle arrest at the G0/G1 phase, and triggered apoptosis. When combined with the clinical drug 5-fluorouracil, Cedrol showed synergistic inhibitory effects on CRC cell growth. In vivo, Cedrol suppressed the progression of CRC and improved the survival rate of animals. The study concluded that Cedrol could be an effective agent for CRC therapy.