The Effect of Different Concentrations of All-Trans Retinoic Acid on the Growth and Survival of Mouse Hair Follicle Stem Cells

July 2013

Nowruz Najafzadeh, S H Heydari Tajadod, M Mazeni, Nazneen Tata

all-trans retinoic acid hair follicle stem cells apoptotic cell death IC50 retinoic acid skin diseases

TLDR High concentrations of retinoic acid kill hair follicle stem cells, while low concentrations may help treat skin diseases.

The study investigated the effects of different concentrations of all-trans retinoic acid on the growth and survival of hair follicle stem cells derived from Balb/c mice whisker follicles. It was found that concentrations of 10 µM and higher caused apoptotic cell death, with an IC50 value of 14.3 µM. The results suggested that high concentrations of retinoic acid could be used to eliminate redundant hairs, while low concentrations could be beneficial for treating skin diseases.

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The Effect of Different Concentrations of All-Trans Retinoic Acid on the Growth and Survival of Mouse Hair Follicle Stem Cells

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