Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction
May 2017
in “Journal of Dermatological Science”
TLDR Stress can cause early aging in certain skin cells, leading to problems with hair growth.
The 2017 study explored the impact of premature aging of dermal papilla cells on hair follicle aging. The cells were subjected to H2O2 to induce premature aging, and their proliferation, apoptosis, gene expression, and protein secretion were examined. The findings revealed that these cells were more resistant to oxidative stress-induced apoptosis than dermal fibroblasts. However, the surviving cells exhibited signs of aging, lost the capacity to stimulate new hair follicles, encouraged epidermal differentiation, inhibited follicular differentiation, and suppressed hair follicle stem cell growth. They also generated higher levels of inflammatory cytokines, including IL-6, which hindered clonal keratinocyte growth in vitro and obstructed the transition from telogen to anagen in vivo. The study concluded that stress-induced premature aging of dermal papilla cells can contribute to hair follicle aging due to compromised epithelial-mesenchymal interaction.
View this study on jdsjournal.com →
Cited in this study
research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
research Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
Blocking JAK-STAT signaling can lead to hair growth.
research Age-related hair changes in men: Mechanisms and management of alopecia and graying
Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.
research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
research Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
research Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells
Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.
research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage
Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
research Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline
More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
research Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration
Larger spheroids improve hair growth, but size doesn't guarantee thicker hair.
research Age-associated inflammation inhibits epidermal stem cell function
research Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells
The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.
research Prostaglandin D 2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
PGD2 stops hair growth and is higher in bald men with AGA.
research Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells
Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
research How real is senescent alopecia? A histopathologic approach
Aging alone rarely causes significant hair loss; hormones are a bigger factor.
research Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins
Skin-derived precursors in hair follicles come from different origins but function similarly.
research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle
New cells are added to the hair's dermal papilla during the active growth phase.
research Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin
Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.
research Epidermal homeostasis: a balancing act of stem cells in the skin
Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
research Developmental timing of hair follicle and dorsal skin innervation in mice
research Hair density, hair diameter and the prevalence of female pattern hair loss
FPHL affects hair density and diameter, causing visible hair loss in older women.
research Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways
There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
research A comparison of the culture and growth of dermal papilla cells from hair follicles from non-balding and balding (androgenetic alopecia) scalp
research Quantitative study of the human hair follicle in normal scalp and androgenetic alopecia
Alopecia causes smaller hair follicles and affects growth-related structures.
Related
research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin
Special particles from skin cells can promote hair growth by activating a specific growth signal.
research A model system to analyse the ability of human keratinocytes to form hair follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Dermal papilla cells induce keratinocyte tubulogenesis in culture
Skin cells can help create early hair-like structures in lab cultures.
research Optimization of the reconstruction of dermal papilla like tissues employing umbilical cord mesenchymal stem cells
research The multipotency of adult vibrissa follicle stem cells
Adult vibrissa follicle stem cells can regenerate hair follicles, glands, and skin.