Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering
May 2013
in “Journal of Dermatological Science”
TLDR Improving the environment and cell interactions is key for creating human hair in the lab.
The document from May 1, 2013, reviews strategies to enhance epithelial-mesenchymal interactions (EMIs) crucial for the bioengineering of human hair follicles. It emphasizes the importance of optimizing the environment and cellular components to promote EMIs, including the use of growth factors, hormones, and extracellular matrices to maintain the hair inductive capacity of dermal papilla cells. The document also discusses the formation of cell aggregates, the potential of various cell types such as mesenchymal stem cells and induced pluripotent stem cells, and the use of in vivo hair reconstitution assays. It suggests that humanized in vivo conditions and careful step-by-step experimentation are key to intensifying EMIs and achieving successful hair follicle regeneration.
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research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo
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Forming spheres boosts the ability of certain human cells to create hair follicles when mixed with mouse skin cells.
research De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro
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research The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization
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research Review of hair follicle dermal cells
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research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
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research TGF‐β2 is specifically expressed in human dermal papilla cells and modulates hair folliculogenesis
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research A Human Folliculoid Microsphere Assay for Exploring Epithelial– Mesenchymal Interactions in the Human Hair Follicle
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research Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
Laminin-511 is crucial for early hair growth and maintaining important hair development signals.
research Hair Follicle Regeneration Using Grafted Rodent and Human Cells
Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.
research Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
research Bioengineering the Hair Follicle
Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.
research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells
Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.
research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla
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research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
research Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth
Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research WNT Signaling in the Control of Hair Growth and Structure
The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.
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