Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering

    Manabu Ohyama, Ophelia Veraitch
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    TLDR Improving the environment and cell interactions is key for creating human hair in the lab.
    The document from May 1, 2013, reviews strategies to enhance epithelial-mesenchymal interactions (EMIs) crucial for the bioengineering of human hair follicles. It emphasizes the importance of optimizing the environment and cellular components to promote EMIs, including the use of growth factors, hormones, and extracellular matrices to maintain the hair inductive capacity of dermal papilla cells. The document also discusses the formation of cell aggregates, the potential of various cell types such as mesenchymal stem cells and induced pluripotent stem cells, and the use of in vivo hair reconstitution assays. It suggests that humanized in vivo conditions and careful step-by-step experimentation are key to intensifying EMIs and achieving successful hair follicle regeneration.
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