Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

    September 2021 in “ Frontiers in Cell and Developmental Biology ”
    Yufan Zhang, Junfei Huang, Danlan Fu … Yong Miao
    Studysummary This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.
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    Research cited in this study 33

    1. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    2. Platelet-Rich Plasma for Androgenic Alopecia: A Randomized, Placebo-Controlled, Double-Blind Study and Combined Mice Model Experiment Journal of Cosmetic Dermatology · 2021
    3. A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit Genes · 2020
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    5. EZH2-Mediated Inhibition of MicroRNA-22 Promotes Differentiation of Hair Follicle Stem Cells by Elevating STK40 Expression Aging · 2020
    6. LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis Experimental Cell Research · 2020
    7. Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy Nature Communications · 2019
    8. Keratinocytes Maintain Compartmentalization Between Dermal Papilla and Fibroblasts in 3D Heterotypic Tri-Cultures Cell Proliferation · 2019
    9. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    10. The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells Journal of Cosmetic Dermatology · 2019
    11. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    12. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    13. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
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    17. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    18. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    19. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    20. Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia British Journal of Dermatology · 2011
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    22. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    23. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    24. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    25. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    26. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    27. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
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    Related research 1

    1. Comparative Study of Some Potential Paracrine Factors Produced by Normal and Androgenetic Alopecia Hair Follicles American journal of medical and biological research · 2015