TLDR DHT stops hair regrowth in mice, similar to human hair loss.
This study found that dihydrotestosterone (DHT) inhibits hair regrowth in mice by activating the androgen receptor, which is similar to androgenetic alopecia (AGA) in humans. The study suggests that targeting the androgen receptor could be a potential treatment for AGA. The study also developed a mouse model that mimics human AGA. The drug bicalutamide partially reverses the effect of DHT. The study found that DHT can cause hair loss in mice by activating androgen receptors in hair follicles, inhibiting hair regrowth.View this study on sciencedirect.com →
Androgens prevent hair growth by changing Wnt signals in cells.
Multiple treatments work best for hair loss.
Wnt/β-catenin and TGF-β pathways affect hair loss, and activating Wnt/β-catenin could be a potential treatment.
Sebaceous glands in male pattern hair loss patients have more lobules and might cause early hair growth phase shifts.
Forsythiaside-A, a natural substance, can protect against hair loss and is more effective than current treatments, potentially making it a good option for hair loss treatment.
Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
Mice with human gene experienced hair loss when treated with DHT.
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
Minoxidil promotes hair regrowth in early baldness stages and prevents baldness in non-bald scalps.