Differentiation genes were governed by DNA methylation during hair follicle morphogenesis in Cashmere goat

January 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Shanhe Wang, Fang Li, Jinwang Liu, Yuelang Zhang, Yujie Zheng, Wei Ge, Lei Qu, Xin Wang

DNA methylation hair follicle morphogenesis Hoxc13 Sox9 Gata3 long non-coding RNAs lncRNA XR_001918556 lnc-003786 Fgfr2

TLDR DNA methylation controls hair follicle gene expression in cashmere goats.

This study investigated the role of DNA methylation in hair follicle morphogenesis in cashmere goats, focusing on embryonic day 65 and 120 skin tissues. It was found that DNA methylation negatively correlated with the expression of hair follicle differentiation genes and transcription factors, such as Hoxc13, Sox9, and Gata3. These genes were methylated and repressed during the hair follicle induction stage but were demethylated and expressed during the differentiation stage. The study also identified long non-coding RNAs (lncRNAs) that may influence DNA methylation, such as lncRNA XR_001918556 affecting Gata3 and lnc-003786 affecting Fgfr2. The findings highlighted the importance of DNA methylation in regulating gene expression during hair morphogenesis and expanded the understanding of the molecular mechanisms involved.

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