Dermal Papilla Cell-Derived Exosomes Promote Hair Follicle Regeneration During Wound Healing by Activating Wnt/Beta-Catenin Signaling Pathway

The study found that dermal papilla cell-derived exosomes (DPC-Exos) can promote hair follicle (HF) regeneration during wound healing. This is achieved by enhancing the proliferation, migration, and hair-inducing capacity of fibroblasts. When fibroblasts treated with DPC-Exos were combined with neonatal mice epidermal cells, they induced HF neogenesis in nude mice. In vivo experiments showed that DPC-Exos could accelerate wound re-epithelialization and promote HF regeneration. The expression levels of Wnt pathway transcription factor β-catenin and Lef1 were elevated in fibroblasts and the dermis of skin wounds after DPC-Exos treatment. This suggests that DPC-Exos could be a promising therapeutic strategy for skin wound regenerative healing.