Dermal Papilla Cell-Derived Exosomes Promote Hair Follicle Regeneration During Wound Healing by Activating Wnt/Beta-Catenin Signaling Pathway

February 2024 in “ Research Square (Research Square) ”

Yuanyuan Shang, Mengyang Li, Lixia Zhang, Chunmao Han, Kuo Shen, Kejia Wang, Yan Li, Yue Zhang, Liang Luo, Yali Jia, Kai Guo, Wenju Cai, Jian Zhang, Xujie Wang, Hongtao Wang, Dahai Hu

dermal papilla cell-derived exosomes DPC-Exos hair follicle regeneration Wnt/β‐catenin signaling pathway fibroblasts neogenesis wound re-epithelialization Lef1 exosomes Wnt signaling β-catenin wound healing

Studysummary In this study, researchers found that exosomes derived from dermal papilla cells can enhance hair follicle regeneration during wound healing in nude mice by promoting fibroblast activation and stimulating the Wnt/β-catenin signaling pathway, suggesting their potential as a therapeutic strategy for regenerative skin healing. Our plain-language summary of this paper — not a Tressless recommendation.

The study found that dermal papilla cell-derived exosomes (DPC-Exos) can promote hair follicle (HF) regeneration during wound healing. This is achieved by enhancing the proliferation, migration, and hair-inducing capacity of fibroblasts. When fibroblasts treated with DPC-Exos were combined with neonatal mice epidermal cells, they induced HF neogenesis in nude mice. In vivo experiments showed that DPC-Exos could accelerate wound re-epithelialization and promote HF regeneration. The expression levels of Wnt pathway transcription factor β-catenin and Lef1 were elevated in fibroblasts and the dermis of skin wounds after DPC-Exos treatment. This suggests that DPC-Exos could be a promising therapeutic strategy for skin wound regenerative healing.

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58 citations , March 2019 in “Experimental Dermatology”

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76 citations , August 2018 in “International Journal of Cosmetic Science”

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