Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix
September 2017
in “European Journal of Cell Biology”
TLDR CIP/KIP proteins help stop cell division and support hair growth.
The study characterized cell cycle arrest and terminal differentiation in human hair follicle matrix keratinocytes, focusing on the role of CIP/KIP family proteins (p21CIP1, p27KIP1, and p57KIP2). These proteins regulated cell cycle progression, arrest, and differentiation, with p21CIP1 and p27KIP1 persisting in post-mitotic keratinocytes and p57KIP2 becoming nuclear. The expression of these proteins coincided with reduced cell cycle activity markers, indicating a post-mitotic state. The findings suggested that CIP/KIP proteins support cell cycle arrest, differentiation, and anti-apoptotic pathways, promoting continuous hair bulb growth and hair shaft formation. The study used samples from 23 patients and highlighted the HF as a model for studying cell cycle physiology in human epithelial cells.
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