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Glossaryp21 (p21Cip1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

30 citations, April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Skin Melanocytes: Biology and Development

401 citations, January 2013 in “Postepy Dermatologii I Alergologii”

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

research Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

295 citations, September 2006 in “Cell Cycle”

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

research Roles of Jumonji and Jumonji Family Genes in Chromatin Regulation and Development

178 citations, May 2006 in “Developmental Dynamics”

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

research Extraskeletal Actions of Vitamin D

119 citations, July 2016 in “Annals of the New York Academy of Sciences”

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

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