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Glossaryp21 (p21Cip1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research The Simplest Protocol for Rapid and Long-Term Culture of Primary Epidermal Keratinocytes from Human and Mouse

2 citations , January 2019 in “Methods in molecular biology”

A new method helps grow skin cells from humans and mice more easily and quickly.

research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2

49 citations , August 1999 in “Journal of Investigative Dermatology”

Overexpressing the MSX-2 gene in mice causes skin and hair growth issues.

research Cyclin-Dependent Kinase Inhibitors, P21waf1/Cip1 And P27kip1, Are Expressed Site- And Hair Cycle-Dependently In Rat Hair Follicles

9 citations , February 2001 in “Journal of Dermatological Science”

p21waf1/cip1 and p27kip1 help in hair follicle differentiation in rats.

Signal Integrator Function of CXXC5 in Cancer

research Signal Integrator Function of CXXC5 in Cancer

January 2025 in “Cell Communication and Signaling”

CXXC5 can both suppress and promote cancer, making it a complex target for treatment.

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