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Glossaryp21 (WAF1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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Accelerated Senescence in Skin in a Murine Model of Radiation-Induced Multi-Organ Injury

research Accelerated Senescence in Skin in a Murine Model of Radiation-Induced Multi-Organ Injury

19 citations , February 2017 in “Journal of radiation research”

High-dose radiation speeds up aging in skin stem cells.

HIF-2α/ARNT Complex Regulates Hair Development via Induction of p21 Waf1/Cip1 and p27 Kip1

research HIF-2α/ARNT Complex Regulates Hair Development via Induction of p21 Waf1/Cip1 and p27 Kip1

4 citations , March 2014 in “The FASEB Journal”

The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.

Effect of Lithocholic Acid as a Ligand of Vitamin D Receptor on Hair Growth in Alopecia

research Effect of Lithocholic Acid as a Ligand of Vitamin D Receptor on Hair Growth in Alopecia

April 2016 in “Journal of Investigative Dermatology”

Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

Effect of Prostaglandin D2 on Hair Follicle Growth and Its Impact on Hair Follicle Stem/Progenitor Cells

research Effect of Prostaglandin D2 on Hair Follicle Growth and Its Impact on Hair Follicle Stem/Progenitor Cells

1 citations , April 2016 in “Journal of Investigative Dermatology”

Blocking Prostaglandin D₂ may help treat hair loss.

Lysocellin, a Metabolite of the Novel Drug Alopestatin, Induces G1 Arrest and Prevents Cytotoxicity Induced by Etoposide

research Lysocellin, a Metabolite of the Novel Drug Alopestatin, Induces G1 Arrest and Prevents Cytotoxicity Induced by Etoposide

1 citations , April 2006 in “International Journal of Oncology”

Lysocellin helps stop cell damage from etoposide and may prevent hair loss.

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