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Glossaryp21 (CIP1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations, March 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

research A Pair of Transmembrane Receptors Essential for the Retention and Pigmentation of Hair

11 citations, May 2012 in “Genesis”

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations, February 2013 in “Cell reports”

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep

research Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep

19 citations, June 2020 in “Animals”

Poor maternal nutrition can lead to fewer wool follicles in Chinese Merino sheep.

Adipocytes in Skin Health and Disease

research Adipocytes in Skin Health and Disease

77 citations, March 2014 in “Cold Spring Harbor Perspectives in Medicine”

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

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