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Glossaryp21 (CIP1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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research Cyclin-Dependent Kinase Inhibitors, P21waf1/Cip1 And P27kip1, Are Expressed Site- And Hair Cycle-Dependently In Rat Hair Follicles

9 citations , February 2001 in “Journal of Dermatological Science”

p21waf1/cip1 and p27kip1 help in hair follicle differentiation in rats.

P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

research P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.

research HIF-2α/ARNT Complex Regulates Hair Development via Induction of p21 Waf1/Cip1 and p27 Kip1

4 citations , March 2014 in “The FASEB Journal”

The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.

research Effect of Lithocholic Acid as a Ligand of Vitamin D Receptor on Hair Growth in Alopecia

April 2016 in “Journal of Investigative Dermatology”

Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

research Lysocellin, a Metabolite of the Novel Drug Alopestatin, Induces G1 Arrest and Prevents Cytotoxicity Induced by Etoposide

1 citations , April 2006 in “International Journal of Oncology”

Lysocellin helps stop cell damage from etoposide and may prevent hair loss.

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