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Glossaryp21 (CIP1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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13 / 13 results

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations, March 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

research A Pair of Transmembrane Receptors Essential for the Retention and Pigmentation of Hair

11 citations, May 2012 in “Genesis”

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations, February 2013 in “Cell reports”

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

research Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep

19 citations, June 2020 in “Animals”

Poor maternal nutrition can lead to fewer wool follicles in Chinese Merino sheep.

research Adipocytes in Skin Health and Disease

77 citations, March 2014 in “Cold Spring Harbor Perspectives in Medicine”

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

research Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry

October 2012 in “Humana Press eBooks”

Grape seed extract is good for skin care, with antioxidant, anti-inflammatory, and anti-cancer effects.

research Role of the Wnt Signaling Pathway in Keratoacanthoma

2 citations, November 2019 in “Cancer reports”

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

research Activation of Androgen Receptor Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations, December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

research Epidermal Stem Cell Diversity and Quiescence

168 citations, August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

research Dihydrotestosterone Induces p27 Degradation via Direct Binding with SKP2 in Ovarian and Breast Cancer

18 citations, April 2011 in “International Journal of Molecular Medicine”

Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.

research Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

295 citations, September 2006 in “Cell Cycle”

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

research The Role of Pannexin 3 in Bone Biology

32 citations, November 2016 in “Journal of Dental Research”

Pannexin 3 is important for bone formation and the development of bone cells.

research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

695 citations, October 2011 in “Cell stem cell”

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.