Who Tells the Story of the Treatment of Androgenetic Alopecia? A Bibliometric Analysis From 2003 to 2023

August 2025 in “ Journal of Cosmetic Dermatology ”

Yulin Sun, Mingyang Lu, Xuejun Gao, Yutong Liu, Jizhen Ren, Yanjin Wang, Xia Cai

androgenetic alopecia platelet-rich plasma anti-androgen therapy microneedling stem cell therapy gene therapy AGA PRP

TLDR Interest in new and personalized treatments for hair loss is growing.

The bibliometric analysis of androgenetic alopecia (AGA) research from 2003 to 2023 identifies 2,203 studies, with the USA leading in research output. Key treatments explored include anti-androgen therapies like finasteride, novel topical inhibitors such as Clascoterone and Pyrilutamide, and platelet-rich plasma (PRP) therapy, which is effective with minimal side effects. Emerging treatments like Botulinum Toxin A (BTA) injections and microneedle therapy show promise. The study also highlights the potential of stem cell and gene therapies, particularly adipose-derived stem cells and genetic loci related to AGA, to revolutionize treatment. Despite advancements, no permanent cure exists, underscoring the need for ongoing research and innovation.

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Research cited in this study

28 / 28 results

Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on Botulinum Toxin for Androgenetic Alopecia

research Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on Botulinum Toxin for Androgenetic Alopecia

June 2024 in “Dermatology and therapy”

Intramuscular injections improved hair density more than intradermal injections for treating hair loss.

Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia

research Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia

May 2024 in “Nano letters”

Polydopamine and quercetin together can speed up hair regrowth.

research Androgenetic Alopecia: A Review

April 2024 in “Nigerian Postgraduate Medical Journal”

Androgenetic alopecia is a common hair loss condition influenced by various factors and linked to psychosocial and cardiovascular issues.

Characterization of Distinct Microbiota Associated With Androgenetic Alopecia Patients Treated and Untreated With Platelet-Rich Plasma

research Characterization of Distinct Microbiota Associated With Androgenetic Alopecia Patients Treated and Untreated With Platelet-Rich Plasma

April 2024 in “Animal models and experimental medicine”

PRP treatment helps hair growth and rebalances scalp bacteria in androgenetic alopecia patients.

research Trichoscopy Features of Indonesian Males with Androgenetic Alopecia in Association with Disease Severity

July 2023 in “International journal of trichology”

The research found no clear link between the severity of male baldness and the scalp examination findings in Indonesian men.

research Cell Therapy for Androgenetic Alopecia: Elixir or Trick?

June 2023 in “Stem cell reviews and reports”

Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.

research Androgenetic Alopecia: Therapy Update

May 2023 in “Drugs”

There are many treatments for common hair loss, but more trials are needed to decide which are best.

research Human Stem Cell Use in Androgenetic Alopecia: A Systematic Review

March 2023 in “Cells”

Stem cell treatments show promise for hair loss but need more research.

research Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

8 citations , October 2022 in “Regenerative Therapy”

New regenerative treatments for hair loss show promise but need more research for confirmation.

research A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia

2 citations , August 2022 in “Aesthetic Plastic Surgery”

research A Study of Combination Unilateral Subcutaneous Botulinum Toxin A Treatment for Androgenetic Alopecia

June 2022 in “Journal of Cosmetic Dermatology”

Adding botulinum toxin A to standard hair loss treatments improves hair growth.

research Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

18 citations , March 2022 in “Drug design, development and therapy”

Platelet-rich plasma (PRP) may help with various hair loss types, but more research is needed to find the best use method.

research Microneedling and Its Use in Hair Loss Disorders: A Systematic Review

2 citations , December 2021 in “Dermatology and therapy”

Microneedling helps with hair loss, especially with 5% minoxidil, but more high-quality research is needed.

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

research Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

24 citations , September 2020 in “Dermatology and therapy”

Oral minoxidil 5 mg daily increases hair growth safely in men with hair loss, with minor side effects.

research Efficacy and Safety of Oral Minoxidil in Female Androgenetic Alopecia

14 citations , September 2020 in “Dermatologic Therapy”

Oral minoxidil improves hair density in women with androgenetic alopecia, with mild side effects.

research Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial

33 citations , July 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

research The Effect of Intradermal Botulinum Toxin on Androgenetic Alopecia and Its Possible Mechanism

15 citations , April 2020 in “Journal of The American Academy of Dermatology”

Botulinum toxin injections may help treat hair loss by blocking harmful secretion in hair follicles.

research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

19 citations , April 2020 in “Dermatologic Therapy”

Dutasteride works better than finasteride for hair loss, with both being safe to use.

research Safety of Oral Bicalutamide in Female Pattern Hair Loss: A Retrospective Review of 316 Patients

16 citations , March 2020 in “Journal of The American Academy of Dermatology”

Oral bicalutamide is safe and effective for female hair loss.

research Oral Bicalutamide for Female Pattern Hair Loss: A Pilot Study

8 citations , October 2019 in “Dermatologic Therapy”

Bicalutamide improves hair density in women safely.

A Summary of In Vitro, Phase I, and Phase II Studies Evaluating the Mechanism of Action, Safety, and Efficacy of Clascoterone (Cortexolone 17a Propionate, CB-03-01) in Androgenetic Alopecia

research A Summary of In Vitro, Phase I, and Phase II Studies Evaluating the Mechanism of Action, Safety, and Efficacy of Clascoterone (Cortexolone 17a Propionate, CB-03-01) in Androgenetic Alopecia

3 citations , August 2019 in “Journal of The American Academy of Dermatology”

Clascoterone safely promotes hair growth similar to minoxidil.

research Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss

13 citations , August 2018 in “Facial Plastic Surgery Clinics of North America”

Adipose tissue shows promise for hair regrowth, but more research is needed to confirm best practices and effectiveness.

research Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

53 citations , June 2017 in “Skin appendage disorders”

PRP treatment helps hair growth in most cases, but more research needed.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research The Diagnosis and Treatment of Hair and Scalp Diseases

37 citations , May 2016 in “Deutsches Arzteblatt International”

Hair loss requires customized treatments based on its various causes and types.

research Androgenetic Alopecia: Overview, Epidemiology, Pathophysiology, and Treatment

11 citations , September 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Various treatments exist for hair loss, but more research is needed for better options.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations , June 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

research Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss

185 citations , March 2011 in “The Journal of Sexual Medicine”

Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.

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