Characterization of Distinct Microbiota Associated With Androgenetic Alopecia Patients Treated and Untreated With Platelet-Rich Plasma

April 2024 in “ Animal models and experimental medicine ”

Qian S. Zhang, Y. Ken Wang, Cheng Ran, Yingmei Zhou, Zhiyun Zhao, Tianning Xu, Hongwei Hou, Yuan Liu

androgenetic alopecia platelet-rich plasma PRP Cutibacterium Staphylococcus Firmicutes Proteobacteria Actinobacteriota scalp microbiota AGA

TLDR PRP treatment helps hair growth and rebalances scalp bacteria in androgenetic alopecia patients.

The study examined the impact of platelet-rich plasma (PRP) treatment on the scalp microbiota of 14 androgenetic alopecia (AGA) patients over six months. PRP treatment resulted in significant hair growth and changes in microbial populations, with an increase in Cutibacterium and a decrease in Staphylococcus, suggesting a shift towards a healthier scalp microbiota. Although alpha and beta diversity analyses showed no significant differences, specific bacterial groups like Firmicutes, Proteobacteria, and Actinobacteriota exhibited changes in relative abundance. The study highlights PRP's effectiveness in treating AGA and the potential role of scalp microbiota in its development and treatment, warranting further research to understand these mechanisms.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics

11 citations, February 2021 in “Biomedicines”

Bacteria in our hair can affect its health and growth, and studying these bacteria could help us understand hair diseases better.

Characteristics of Healthy and Androgenetic Alopecia Scalp Microbiome: Effect of Lindera Strychnifolia Roots Extract as a Natural Solution for Its Modulation

research Characteristics of Healthy and Androgenetic Alopecia Scalp Microbiome: Effect of Lindera Strychnifolia Roots Extract as a Natural Solution for Its Modulation

2 citations, August 2020 in “International Journal of Cosmetic Science”

Lindera strychnifolia root extract may help balance scalp bacteria and potentially reduce hair loss.

research Platelet-Rich Plasma as a Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis

15 citations, May 2020 in “Journal of Dermatological Treatment”

PRP treatment increases hair density and thickness in androgenetic alopecia by 79%.

research The Role of the Microbiome in Scalp Hair Follicle Biology and Disease

73 citations, April 2019 in “Experimental Dermatology”

The scalp's microorganisms significantly affect hair health and disease.

research Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health

65 citations, October 2018 in “Frontiers in cellular and infection microbiology”

Certain bacteria and fungi are linked to healthy scalps and dandruff, suggesting that the scalp's microbial balance affects its health.

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis

54 citations, May 2018 in “Journal of The European Academy of Dermatology and Venereology”

Low level laser therapy works best for hair loss, followed by PRP, finasteride, and minoxidil.

A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors

research A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors

30 citations, December 2017 in “Medical Hypotheses”

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations, April 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Classifications of Patterned Hair Loss: A Review

101 citations, January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.

research Finasteride

187 citations, January 1994 in “The New England Journal of Medicine”

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

53 citations, May 1990 in “Journal of Dermatology”

Minoxidil speeds up hair growth in rats without prolonging growth phase.

Related Community Posts Join

6 / 1000+ results

community Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

in Research/Science 3 upvotes 1 year ago

The review discusses traditional hair loss treatments like minoxidil and finasteride, and newer options like Low-Level Laser Therapy, microneedling, and platelet-rich plasma for androgenetic alopecia. It highlights the need for more high-quality trials to assess these treatments' effectiveness and standardized protocols for emerging therapies.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 15 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Related Research

5 / 5 results

Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

research The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

41 citations, December 2008 in “International Journal of Dermatology”

South Korean women with hair loss have lower hair density and thickness compared to healthy women.