Baseline Neutrophil-to-Lymphocyte Ratio Stratifies Early Trichoscopic Response to Platelet-Rich Plasma–Based Regimens in Non-Scarring Alopecia: A Real-World Cohort with Internal Validation Using an Interpretable Neural Network

The study explored the use of baseline neutrophil-to-lymphocyte ratio (NLR) as a predictor of early response to platelet-rich plasma (PRP)-based treatments in non-scarring alopecia, involving 129 patients. It found that a higher NLR (>2.202) significantly increased the risk of non-response in hair density, with a 15.49-fold higher risk of treatment failure. The study suggests that NLR could serve as a valuable predictor for PRP treatment outcomes, although further validation is needed before clinical application. The research highlights the potential of using NLR as a low-cost biomarker to tailor hair loss therapies, despite limitations such as non-randomized treatment allocation and the need for external validation.