Complete Blood Collection-Based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-Sectional Study

October 2024 in “ Acta Dermato Venereologica ”

Sihan Deng, Jundong Huang, Min Li, Jian Jia, Wei Shi

alopecia areata systemic inflammation neutrophil/lymphocyte ratio systemic immune inflammation index white blood cell/lymphocyte ratio platelet/lymphocyte ratio AA NLR SII WLR PLR

TLDR Higher inflammation markers are linked to more severe alopecia areata.

This study involving 302 alopecia areata (AA) patients and 296 healthy controls found that systemic inflammation biomarkers, specifically neutrophil/lymphocyte ratio (NLR), systemic immune inflammation index (SII), and white blood cell/lymphocyte ratio (WLR), were significantly higher in AA patients. Furthermore, platelet/lymphocyte ratio (PLR) and SII were notably elevated in patients with severe AA compared to those with mild-to-moderate AA. The findings suggest that elevated levels of these biomarkers are associated with an increased risk of severe AA, indicating a strong link between systemic inflammation and the severity of the disease.

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