Complete Blood Collection-Based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-Sectional Study

October 2024 in “ Acta Dermato Venereologica ”

Sihan Deng, Jundong Huang, Min Li, Jian Jia, Wei Shi

alopecia areata systemic inflammation neutrophil/lymphocyte ratio systemic immune inflammation index white blood cell/lymphocyte ratio platelet/lymphocyte ratio AA NLR SII WLR PLR

Studysummary This study found that patients with alopecia areata had higher systemic inflammation markers compared to healthy controls, and these markers were associated with a greater risk of severe disease. Our plain-language summary of this paper — not a Tressless recommendation.

This study involving 302 alopecia areata (AA) patients and 296 healthy controls found that systemic inflammation biomarkers, specifically neutrophil/lymphocyte ratio (NLR), systemic immune inflammation index (SII), and white blood cell/lymphocyte ratio (WLR), were significantly higher in AA patients. Furthermore, platelet/lymphocyte ratio (PLR) and SII were notably elevated in patients with severe AA compared to those with mild-to-moderate AA. The findings suggest that elevated levels of these biomarkers are associated with an increased risk of severe AA, indicating a strong link between systemic inflammation and the severity of the disease.

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Research cited in this study

7 / 7 results

research The Alopecia Areata Severity And Morbidity Index (ASAMI) Study

21 citations , February 2024 in “JAMA Dermatology”

This study identified multiple factors affecting the severity of alopecia areata, suggesting they could inform a tool for measuring disease impact and guide treatment selection.

research Comorbid Conditions Associated With Alopecia Areata: A Systematic Review and Meta-Analysis

51 citations , July 2023 in “American Journal of Clinical Dermatology”

research Novel Potential Therapeutic Targets of Alopecia Areata

1 citations , April 2023 in “Frontiers in Immunology”

This review explored recent research on the immune mechanisms and potential therapeutic targets for alopecia areata, highlighting the roles of immune-related cells, autocrine and paracrine signaling, as well as factors like adipose-derived stem cells and gut microbiota in disease pathogenesis.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

This study found that dysregulation of systemic Th1, Th2, and Th17 cytokines is associated with alopecia areata, with specific cytokines linked to disease activity and treatment response.

Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

30 citations , July 2019 in “PloS one”

This study found that T-regulatory cells, specifically the FOXP3 CD39 subset, were significantly reduced in both circulation and hair follicles of alopecia areata patients compared to healthy subjects, suggesting potential therapeutic targets.

Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

This background review discusses alopecia areata, highlighting the role of CD8+NKG2D+ T cells in hair follicle pathogenesis, and notes that the exact mechanisms causing hair loss remain unclear.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.