Systemic Inflammation Marker Alterations in Severe Alopecia Areata Patients Treated with Janus Kinase Inhibitors

    January 2026 in “ Journal of Clinical Medicine ”
    Gokhan Sahin, Fatma Aydin, Esra Pancar Yüksel
    Studysummary The study found that systemic inflammatory markers were elevated in patients with severe alopecia areata compared to those with mild disease and healthy controls, and these markers decreased in patients who improved after JAK inhibitor therapy.
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    Research cited in this study 8

    1. A Three-Step Diagnostic Algorithm for Alopecia: Pattern Analysis in Trichoscopy Journal of Clinical Medicine · 2025
    2. Complete Blood Collection-Based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-Sectional Study Acta Dermato Venereologica · 2024
    3. Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients Dermatology Practical & Conceptual · 2024
    4. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    5. Alopecia Areata: What's New in the Epidemiology, Comorbidities, and Pathogenesis? Journal of Dermatological Science · 2023
    6. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    7. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    8. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016