Androgenetic Alopecia

March 2021 in “ Uludağ Üniversitesi Tıp Fakültesi dergisi ”

Gökhan ŞAHİN, Hilal Ozdemir, Fatma Aydın

androgenetic alopecia follicular miniaturization potassium ion channel modifiers topical minoxidil oral minoxidil 5α reductase inhibitors oral finasteride topical finasteride oral dutasteride androgen receptor antagonists combination therapies androgenic alopecia hair follicle shrinkage minoxidil Rogaine Propecia Avodart

TLDR The review provided information on various treatments to stop hair thinning and increase hair density in people with common genetic hair loss.

Three years ago, a review was conducted on the management of androgenetic alopecia, a common form of hair loss in genetically predisposed individuals. The review noted that there was no standard treatment guideline for this condition, with the goal of management being to halt follicular miniaturization and increase hair density. Various therapies were used, including potassium ion channel modifiers (like topical and oral minoxidil), 5α reductase inhibitors (like oral finasteride, topical finasteride, and oral dutasteride), androgen receptor antagonists, other medical treatments, physical treatments, complementary therapies, and combination therapies. The review aimed to provide information about these current treatment methods for both men and women.

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research Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial

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New treatments for hair loss show promise, but more research is needed to confirm their safety and effectiveness.

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Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

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Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.

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PRP treatment helps hair growth and density in androgenetic alopecia patients.

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research Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

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research New Investigational Drugs for Androgenetic Alopecia

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Finasteride helps hair growth but may cause sexual side effects.

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64 citations , June 2010 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride improves hair density and thickness in women with hair loss.

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92 citations , June 2010 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.

research Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss

53 citations , May 2010 in “PubMed”

Spironolactone helps regrow hair in women with hair loss.

research Mesotherapy in the Management of Hair Loss: Is It of Any Use?

25 citations , January 2010 in “International Journal of Trichology”

Mesotherapy for hair loss lacks evidence of effectiveness and safety and should not be used without further scientific support.

research Successful Treatment of Female-Pattern Hair Loss with Spironolactone in a 9-Year-Old Girl

26 citations , April 2009 in “Australasian Journal of Dermatology”

Spironolactone successfully treated hair loss in a 9-year-old girl.

research Hair Loss in Women: Comprehensive Overview and Treatment Options

81 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

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57 citations , January 2009 in “Indian Journal of Dermatology, Venereology and Leprology”

Finasteride gel is slightly more effective than the tablet for treating hair loss.

research Follicular Streamers (Stelae) in Scarring and Non-Scarring Alopecia

29 citations , July 2008 in “Journal of Cutaneous Pathology”

Hair root sheaths are more common in non-scarring hair loss and help diagnose the type of hair loss.

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

142 citations , August 2007 in “Journal of The American Academy of Dermatology”

New 5% minoxidil foam effectively promotes hair growth and is safe for use.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research Finasteride Induced Depression: A Prospective Study

99 citations , October 2006 in “BMC clinical pharmacology”

Finasteride may cause slight depression and anxiety.

research Effects of Finasteride (1 mg) on Hair Transplant

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Finasteride improves surrounding scalp hair and increases hair density after hair transplant.

Health-Related Quality of Life and Physical Well-Being Among a 63-Year-Old Cohort of Women With Androgenetic Alopecia: A Finnish Population-Based Study

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24 citations , August 2005 in “Health and Quality of Life Outcomes”

Women with androgenetic alopecia experience worse physical well-being and quality of life, but similar mental health compared to those without it.

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72 citations , March 2005 in “British Journal of Dermatology”

AGA can occur in children with family history; early diagnosis and treatment important.

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203 citations , December 2004 in “Journal of The American Academy of Dermatology”

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

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4 citations , May 2004 in “Facial Plastic Surgery Clinics of North America”

Hair transplantation helps women with hair loss; understanding and empathy lead to happy patients.

research Finasteride Treatment of Patterned Hair Loss in Normoandrogenic Postmenopausal Women

72 citations , January 2004 in “Dermatology”

Finasteride can slow hair loss and promote growth in postmenopausal women.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

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80 citations , August 2002 in “Journal of Dermatology”

Best hair growth results from combining finasteride and minoxidil.

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17 citations , August 2002 in “Dermatologic Surgery”

Fluridil safely promotes hair growth in men with androgenetic alopecia.

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149 citations , June 2002 in “British Journal of Dermatology”

Minoxidil works better for female hair loss, but cyproterone reduces scalp oiliness and causes menstrual issues.

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226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women

157 citations , July 2001 in “British Journal of Dermatology”

AGA more common in men, Koreans have lower rates and unique patterns.

research Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia)

6 citations , January 2001 in “Dermatologic Surgery”

Female pattern alopecia is common, starts in late 20s, and is not androgen dependent.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

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Finasteride doesn't effectively treat hair loss in postmenopausal women.

research The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature

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Hair loss affects self-esteem and quality of life; treatments can help.

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50 citations , December 1998 in “Dermatologic Surgery”

Hair loss is more common in men aged 18-49 and increases with age.

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Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

92 citations , January 1998 in “Dermatology”

Ketoconazole shampoo improves hair growth and reduces oil similarly to minoxidil in male pattern hair loss.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

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416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

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309 citations , May 1993 in “Journal of The American Academy of Dermatology”

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

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666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

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