A Guide to Studying Human Hair Follicle Cycling In Vivo

    January 2016 in “Journal of Investigative Dermatology
    Ji Won Oh, Jennifer E. Kloepper, Ewan A. Langan, Yongsoo Kim, Joongyeub Yeo, Min Ji Kim, Tsai‐Ching Hsi, Christian Rosé, Ghil Suk Yoon, Seok Jong Lee, John T. Seykora, Jung Chul Kim, Young Kwan Sung, Moonkyu Kim, Ralf Paus, Maksim V. Plikus
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    TLDR The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.
    The document from 2016 serves as a guide for classifying human hair follicle (HF) cycle stages in vivo, which is essential for hair growth disorder diagnosis and hair research. It introduces a xenograft model using human scalp skin grafted onto mice to study human HF cycling and provides criteria for identifying HF stages, combining morphological and histochemical markers. The guide includes schematic drawings, micrographs, and recommendations for designing experiments, while noting the limitations of murine models due to interspecies differences. It calls for a standardized, accessible guide for human hair cycle staging, aiming to standardize research practices in the field.
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